COCAINE SELF-ADMINISTRATION INCREASES PREPRODYNORPHIN, BUT NOT C-FOS, MESSENGER-RNA IN RAT STRIATUM

被引：153
作者：
DAUNAIS, JB
ROBERTS, DCS
MCGINTY, JF
机构：
[1] E CAROLINA UNIV, SCH MED, DEPT ANAT & CELL BIOL, GREENVILLE, NC 27858 USA
[2] CARLETON UNIV, DEPT PSYCHOL, OTTAWA K1S 5B6, ONTARIO, CANADA
来源：
NEUROREPORT | 1993年 / 4卷 / 05期
关键词：
IMMEDIATE EARLY GENES; DOPAMINE RECEPTORS; OPIOID PEPTIDES; INSITU HYBRIDIZATION; GENE EXPRESSION; NUCLEAR TRANSCRIPTION FACTORS; DRUG ADDICTION;
D O I：
10.1097/00001756-199305000-00020
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
THE impact of cocaine self-administration on the expression of striatal preprodynorphin and c-fos mRNA was examined with in situ hybridization histochemistry. Cocaine significantly increased preprodynorphin mRNA in the dorsal, but not ventral, striatum. Expression of c-fos mRNA in cocaine-administering rats did not differ from that in controls in all structures examined. These results indicate that the expression of preprodynorphin, but not c-fos, is upregulated in rat striatum as a consequence of cocaine self-administration. Furthermore, these data indicate that the regulation of preprodynorphin is dissociable from the expression of c-fos in rats exposed to repeated doses of cocaine.
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收藏
页码：543 / 546
页数：4
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