THE CONVERSION OF AN AZIRIDINE TO A BETA-LACTAM

被引：59

作者：

CHAMCHAANG, W ^{[1
]}

PINHAS, AR ^{[1
]}

机构：

[1] UNIV CINCINNATI,DEPT CHEM,CINCINNATI,OH 45221

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 09期

关键词：

D O I：

10.1021/jo00296a070

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot, inert atmosphere conversion of an aziridine to a β-lactam using nickel tetracarbonyl as the carbonyl source is described. In this reaction it is the less substituted carbon-nitrogen bond which is carbonylated. The proposed mechanism for this reaction requires that a nickel acylate complex attack an alkyl iodide with inversion of configuration. Iron carbonyl complexes are unsuccessful in this carbonylation process. © 1990, American Chemical Society. All rights reserved.

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页码：2943 / 2950

页数：8

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