PRETREATMENT AND HEAVY-METAL LD50 VALUES

被引：27
作者：
JONES, MM [1 ]
SCHOENHEIT, JE [1 ]
WEAVER, AD [1 ]
机构：
[1] VANDERBILT UNIV,CTR TOXICOL,NASHVILLE,TN 37235
来源：
TOXICOLOGY AND APPLIED PHARMACOLOGY | 1979年 / 49卷 / 01期
关键词：
D O I：
10.1016/0041-008X(79)90274-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
LD50 values, with and without pretreatment with the same ion, have been determined in mice for intraperitoneal injection of salts of the ions Cd2+, Hg2+, Ag+, Tl+, Pd2+, Au+, Pt2+, Cu2+, Sn2+, Pt4+, and Zn2+. In the case of Cd2+ the previously reported increase in LD50 values subsequent to pretreatment was confirmed. A statistically significant increase in LD50 values for Hg2+ Ag+, Au+, Cu2+, and Sn2+ subsequent to pretreatment was also observed. © 1979.
引用
收藏
页码：41 / 44
页数：4
相关论文
共 15 条
[1]  
ARMITAGE P, 1971, STATISTICAL METHODS, P122
[2]  
FRIBERG L, 1974, CADMIUM ENV, P54
[3]  
HUANG L, 1977, J BIOL CHEM, V252, P8217
[4]   PRIMARY STRUCTURE OF HUMAN HEPATIC METALLOTHIONEIN [J].
KISSLING, MM ;
KAGI, JHR .
FEBS LETTERS, 1977, 82 (02) :247-250
[5]   MECHANISM FOR CADMIUM-INDUCED AND ZINC-INDUCED TOLERANCE TO CADMIUM TOXICITY - INVOLVEMENT OF METALLOTHIONEIN [J].
LEBER, AP ;
MIYA, TS .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1976, 37 (03) :403-414
[6]  
Pearson R. G., 1973, HARD SOFT ACIDS BASE
[7]  
PIOTROWSKI JK, 1976, J TOXICOL ENV HLTH, V1, P999
[8]   KINETICS OF CADMIUM-INDUCED HEPATIC AND RENAL METALLOTHIONEIN SYNTHESIS IN MOUSE [J].
PROBST, GS ;
BOUSQUET, WF ;
MIYA, TS .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1977, 39 (01) :51-60
[9]   CORRELATION OF HEPATIC METALLOTHIONEIN CONCENTRATIONS WITH ACUTE CADMIUM TOXICITY IN MOUSE [J].
PROBST, GS ;
BOUSQUET, WF ;
MIYA, TS .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1977, 39 (01) :61-69
[10]   MAMMALIAN ZINC HOMEOSTASIS - REQUIREMENT FOR RNA AND METALLOTHIONEIN SYNTHESIS [J].
RICHARDS, MP ;
COUSINS, RJ .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1975, 64 (04) :1215-1223
12