ACCUMULATION OF BENZOPORPHYRIN DERIVATIVE IN MALIGNANT AND HOST-CELL POPULATIONS OF THE MURINE RIF TUMOR

被引：10

作者：

KORBELIK, M

KROSL, G

机构：

[1] Cancer Imaging, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3

来源：

CANCER LETTERS | 1995年 / 97卷 / 02期

基金：

英国医学研究理事会;

关键词：

PHOTODYNAMIC THERAPY; BENZOPORPHYRIN DERIVATIVE; TUMOR LOCALIZATION; TUMOR ASSOCIATED MACROPHAGES;

D O I：

10.1016/0304-3835(95)03985-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The accumulation of benzoporphyrin derivative (BPD) in malignant and host cell populations of the mouse RIF tumor was studied by flow cytometry analysis of cells dissociated from the tumor tissue. The highest cellular BPD levels were found in a subpopulation of tumor associated macrophages (TAMs) characterized by a highly elevated expression of interleukin 2 receptor (F4/80(+)CD25(++)), but this selectivity was less pronounced than with photofrin. The BPD levels in tumor associated immune cells other than TAMs were lower than in malignant cells. No significant difference in cellular distribution of BPD was observed with the photosensitizer delivered in liposomes compared to the aqueous solution.

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页码：249 / 254

页数：6

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