SUPPRESSION OF PLASMA ENDOTHELIN-1 LEVEL BY ALPHA-HUMAN ATRIAL-NATRIURETIC-PEPTIDE AND ANGIOTENSIN-CONVERTING ENZYME-INHIBITION IN NORMAL MEN

被引：12

作者：

UEMASU, J

MATSUMOTO, H

KITANO, M

KAWASAKI, H

机构：

[1] Second Department of Internal Medicine, Tottori University School of Medicine, Yonago

来源：

LIFE SCIENCES | 1993年 / 53卷 / 11期

关键词：

D O I：

10.1016/0024-3205(93)90450-H

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of synthetic alpha-human atrial natriuretic peptide (alpha-hANP) on plasma endothelin-1 (ET-1) level was examined in 6 healthy subjects. Intravenous infusion of alpha-ANP (0.1 mug/kg/min) resulted in significant falls in plasma renin activity and aldosterone, but without effect on ET-1 level. An angiotensin converting enzyme inhibitor, captopril, increased plasma renin activity and decreased aldosterone, respectively. However, plasma ET-1 levels were not modified by captopril. In cases with alpha-hANP infusion after captopril (25 mg, p.o.,), the renin-angiotensin-aldosterone system was further inhibited compared with the first group, and ET- 1 at 60 min was significantly suppressed from the baseline. These data suggest that alpha-hANP when combined with captopril brings about the suppression of plasma ET- 1 concentrations in men.

引用

页码：969 / 974

页数：6

共 19 条

[1] ATRIAL-NATRIURETIC-PEPTIDE - EVIDENCE OF ACTION AS A NATRIURETIC HORMONE AT PHYSIOLOGICAL PLASMA-CONCENTRATIONS IN MAN [J].