SUBSTANCE-P RELEASE FROM SPINAL-CORD SLICES BY CAPSAICIN

被引：374

作者：

GAMSE, R

MOLNAR, A

LEMBECK, F

机构：

[1] Institute of Exper. and Clin. Pharmacology, University of Graz

来源：

LIFE SCIENCES | 1979年 / 25卷 / 07期

关键词：

D O I：

10.1016/0024-3205(79)90558-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The release of substance P (SP) from slices of hypothalamus, substantia nigra and spinal cord of the rat was studied. In contrast to 47 mM potassium, capsaicin induced SP release from spinal cord slices only. The SP release was not reduced by 10-6 M tetrodotoxin but was abolished by a Ca2+ free medium containing 3 mM ethylene-glycol-bis- (β-aminoethyl-ether) N,N-tetraacetic acid (EGTA). Capsaicin induced SP release was dose-dependent and exhibited tachyphylaxis. The ability of capsaicin to release SP supports the hypothesis that SP is involved in pain transmission and in neurogenic plasma extravasation. © 1979.

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页码：629 / 636

页数：8

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