THE BETA-AMYLOID PROTEIN-PRECURSOR OF ALZHEIMER-DISEASE HAS SOLUBLE DERIVATIVES FOUND IN HUMAN-BRAIN AND CEREBROSPINAL-FLUID

被引：262

作者：

PALMERT, MR

PODLISNY, MB

WITKER, DS

OLTERSDORF, T

YOUNKIN, LH

SELKOE, DJ

YOUNKIN, SG

机构：

[1] CASE WESTERN RESERVE UNIV, SCH MED, INST PATHOL, DIV NEUROPATHOL, CLEVELAND, OH 44106 USA

[2] CASE WESTERN RESERVE UNIV, SCH MED, DEPT PHARMACOL, CLEVELAND, OH 44106 USA

[3] HARVARD UNIV, SCH MED, DEPT NEUROL NEUROSCI, BOSTON, MA 02115 USA

[4] ATHENA NEUROSCI INC, S SAN FRANCISCO, CA 94080 USA

[5] BRIGHAM & WOMENS HOSP, CTR NEUROL DIS, BOSTON, MA 02115 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1989年 / 86卷 / 16期

关键词：

D O I：

10.1073/pnas.86.16.6338

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：6338 / 6342

页数：5

共 29 条

[1] LOCALIZATION OF AMYLOID BETA-PROTEIN MESSENGER-RNA IN BRAINS FROM PATIENTS WITH ALZHEIMERS-DISEASE [J].

BAHMANYAR, S ;

HIGGINS, GA ;

GOLDGABER, D ;

LEWIS, DA ;

MORRISON, JH ;

WILSON, MC ;

SHANKAR, SK ;

GAJDUSEK, DC .

SCIENCE, 1987, 237 (4810) :77-80

[2]

CASTANO EM, 1986, BIOCHEM BIOPH RES CO, V141, P781

[3] INSITU HYBRIDIZATION OF NUCLEUS BASALIS NEURONS SHOWS INCREASED BETA-AMYLOID MESSENGER-RNA IN ALZHEIMER-DISEASE [J].

COHEN, ML ;

GOLDE, TE ;

USIAK, MF ;

YOUNKIN, LH ;

YOUNKIN, SG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (04) :1227-1231

[4] COMPUTER-BASED CHARACTERIZATION OF EPIDERMAL GROWTH-FACTOR PRECURSOR [J].

DOOLITTLE, RF ;

FENG, DF ;

JOHNSON, MS .

NATURE, 1984, 307 (5951) :558-560

[5] IDENTIFICATION, TRANSMEMBRANE ORIENTATION AND BIOGENESIS OF THE AMYLOID A4 PRECURSOR OF ALZHEIMERS-DISEASE [J].

DYRKS, T ;

WEIDEMANN, A ;

MULTHAUP, G ;

SALBAUM, JM ;

LEMAIRE, HG ;

KANG, J ;

MULLERHILL, B ;

MASTERS, CL ;

BEYREUTHER, K .

EMBO JOURNAL, 1988, 7 (04) :949-957

[6] ALZHEIMERS-DISEASE - INITIAL REPORT OF THE PURIFICATION AND CHARACTERIZATION OF A NOVEL CEREBROVASCULAR AMYLOID PROTEIN [J].

GLENNER, GG ;

WONG, CW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (03) :885-890

[7] CHARACTERIZATION AND CHROMOSOMAL LOCALIZATION OF A CDNA-ENCODING BRAIN AMYLOID OF ALZHEIMERS-DISEASE [J].

GOLDGABER, D ;

LERMAN, MI ;

MCBRIDE, OW ;

SAFFIOTTI, U ;

GAJDUSEK, DC .

SCIENCE, 1987, 235 (4791) :877-880

[8] THE PRECURSOR OF ALZHEIMERS-DISEASE AMYLOID-A4 PROTEIN RESEMBLES A CELL-SURFACE RECEPTOR [J].

KANG, J ;

LEMAIRE, HG ;

UNTERBECK, A ;

SALBAUM, JM ;

MASTERS, CL ;

GRZESCHIK, KH ;

MULTHAUP, G ;

BEYREUTHER, K ;

MULLERHILL, B .

NATURE, 1987, 325 (6106) :733-736

[9] SYNTHETIC PEPTIDE HOMOLOGOUS TO BETA-PROTEIN FROM ALZHEIMER-DISEASE FORMS AMYLOID-LIKE FIBRILS INVITRO [J].

KIRSCHNER, DA ;

INOUYE, H ;

DUFFY, LK ;

SINCLAIR, A ;

LIND, M ;

SELKOE, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (19) :6953-6957

[10] NOVEL PRECURSOR OF ALZHEIMERS-DISEASE AMYLOID PROTEIN SHOWS PROTEASE INHIBITORY ACTIVITY [J].

KITAGUCHI, N ;

TAKAHASHI, Y ;

TOKUSHIMA, Y ;

SHIOJIRI, S ;

ITO, H .

NATURE, 1988, 331 (6156) :530-532

← 1 2 3 →