Antioxidant, antimicrobial and cytotoxic activities of extracts from some selected mediterranean shrub species (Maquis)

被引：0
作者：
Bayraktar, Oguz [1 ]
Altiok, Evren [2 ]
Yilmazer, Ozgur [3 ]
Ruscuklu, Dane [3 ]
Buyukoz, Melda Y. [4 ]
机构：
[1] Ege Univ, Dept Chem Engn, TR-35100 Bornova, Turkey
[2] Giresun Univ, Dept Bioengn, TR-28200 Gure Giresun, Turkey
[3] Biotechnol & Bioengn Res & Applicat Ctr BIOMER, TR-35430 Urla Izmir, Turkey
[4] Izmir Inst Technol, Dept Bioengn, TR-35430 Urla Izmir, Turkey
来源：
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY | 2016年 / 6卷 / 04期
关键词：
Plant extract; antioxidant activity; antimicrobial activity; cytotoxicity; bax expression;
D O I：
暂无
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
In this study in vitro antioxidant, antimicrobial and cytotoxic activities of ethanol extracts of some plants from Urla region in Turkey were investigated. Plant material samples of Pistacia lentiscus, Vitex agnus-castus, Cistus creticus and Nerium oleander were collected in October, November and December. The harvesting time significantly affected their antioxidant, antimicrobial and cytotoxic activities of these plant extracts. The highest biological activities in terms of antioxidant, antimicrobial and cytotoxic activities were observed for the leaf extract of C. creticus. The applied doses of leaf extracts of C. creticus, P. lentiscus, and N. oleander resulted in higher Bax and GAPDH expressions than those for control cells. These plant extracts may trigger apoptosis and may be a promising natural source for prostate cancer treatment.
引用
收藏
页码：1437 / 1444
页数：8
相关论文
共 44 条
[11]   Antiatherogenic effect of Pistacia lentiscus via GSH restoration and downregulation of CD36 rnRNA expression [J].
Dedoussis, GVZ ;
Kaliora, AC ;
Psarras, S ;
Chiou, A ;
Mylona, A ;
Papdopoulos, NG ;
Andrikopoulos, NK .
ATHEROSCLEROSIS, 2004, 174 (02) :293-303
[12]   Apoptosis - the calcium connection [J].
Demaurex, N ;
Distelhorst, C .
SCIENCE, 2003, 300 (5616) :65-67
[13]   Cytotoxic and anti-inflammatory activity of labdane and cis-clerodane type diterpenes [J].
Demetzos, C ;
Dimas, K ;
Hatziantoniou, S ;
Anastasaki, T ;
Angelopoulou, D .
PLANTA MEDICA, 2001, 67 (07) :614-618
[14]   The effect of sclareol on growth and cell cycle progression of human leukemic cell lines [J].
Dimas, K ;
Kokkinopoulos, D ;
Demetzos, C ;
Vaos, B ;
Marselos, M ;
Malamas, M ;
Tzavaras, T .
LEUKEMIA RESEARCH, 1999, 23 (03) :217-234
[15]   Labdane type diterpenes down-regulate the expression of c-Myc protein, but not of Bcl-2, in human leukemia T-cells undergoing apoptosis [J].
Dimas, K ;
Demetzos, C ;
Vaos, V ;
Ioannidis, P ;
Trangas, T .
LEUKEMIA RESEARCH, 2001, 25 (06) :449-454
[16]   Regulation of apoptosis in prostate cancer [J].
Gurumurthy, S ;
Vasudevan, KM ;
Rangnekar, VM .
CANCER AND METASTASIS REVIEWS, 2001, 20 (3-4) :225-243
[17]   Antimicrobiological studies on Turkish Cistus species [J].
Güvenç, A ;
Yildiz, S ;
Özkan, AM ;
Erdurak, CS ;
Coskun, M ;
Yilmaz, G ;
Okuyama, T ;
Okada, Y .
PHARMACEUTICAL BIOLOGY, 2005, 43 (02) :178-183
[18]   Gum mastic increases maspin expression in prostate cancer cells [J].
He, Mei-Lan ;
Chen, Wei-Wen ;
Zhang, Peng-Ju ;
Jiang, An-Li ;
Fan, Wei ;
Yuan, Hui-Qing ;
Liu, Wen-Wen ;
Zhang, Jian-Ye .
ACTA PHARMACOLOGICA SINICA, 2007, 28 (04) :567-572
[19]   Mechanisms of antiprostate cancer by gum mastic:: NF-κB signal as target [J].
He, Mei-lan ;
Li, Ang ;
Xu, Chun-su ;
Wang, Shun-li ;
Zhang, Meng-jie ;
Gu, Hua ;
Yang, Yao-qin ;
Tao, Hui-hong .
ACTA PHARMACOLOGICA SINICA, 2007, 28 (03) :446-452
[20]   Quantitative high performance liquid chromatographic analysis of casticin in the fruits of Vitex agnus-castus [J].
Hoberg, E ;
Meier, B ;
Sticher, O .
PHARMACEUTICAL BIOLOGY, 2001, 39 (01) :57-61
12345