USE OF AN EPHEDRINE ALKOXIDE TO MEDIATE ENANTIOSELECTIVE ADDITION OF AN ACETYLIDE TO A PROCHIRAL KETONE - ASYMMETRIC-SYNTHESIS OF THE REVERSE-TRANSCRIPTASE INHIBITOR L-743,726

被引：138

作者：

THOMPSON, AS

CORLEY, EG

HUNTINGTON, MF

GRABOWSKI, EJJ

机构：

[1] Department of Process Research Merck Research Laboratories Rahway

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 49期

关键词：

D O I：

10.1016/0040-4039(95)01955-H

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric synthesis of L-743,726 was achieved in six steps with an overall yield of 31%. The asymmetry was introduced using a lithiated ephedrine to mediate acetylide addition to a trifluoromethyl ketone with an enantiomeric excess of 96-98%.

引用

页码：8937 / 8940

页数：4

共 14 条

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