SIGNAL-TRANSDUCTION BY RAS-LIKE GTPASES - A POTENTIAL TARGET FOR ANTICANCER DRUGS

被引：1
|
作者：
SPAARGAREN, M [1 ]
BISCHOFF, JR [1 ]
MCCORMICK, F [1 ]
机构：
[1] ONYX PHARMACEUT,RICHMOND,CA 94806
来源：
GENE EXPRESSION | 1995年 / 4卷 / 06期
关键词：
CANCER; TRANSFORMATION; SIGNAL TRANSDUCTION; GTPASES; RAS; RAF;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Members of the ras family of GTPases are involved in a wide variety of cellular processes including cell proliferation, differentiation, apoptosis, and transformation. The ras oncogene is one of the most frequently mutated genes in human cancer. In addition, other oncogene and tumor suppressor gene products are components of the signal transduction pathways in which Ras or other Ras-like GTPases play key regulatory functions. Current progress in the elucidation of these signal transduction pathways will be reviewed and the potential use of these insights for the development of novel therapeutic agents for the treatment of cancer will be discussed.
引用
收藏
页码：345 / 356
页数：12
相关论文
共 50 条
  • [1] Ras-like GTPases
    Bos, JL
    BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 1997, 1333 (02): : M19 - M31
  • [2] GTP hydrolysis mechanism of Ras-like GTPases
    Li, GP
    Zhang, XJC
    JOURNAL OF MOLECULAR BIOLOGY, 2004, 340 (05) : 921 - 932
  • [3] THE RAS SIGNAL-TRANSDUCTION PATHWAY
    KHOSRAVIFAR, R
    DER, CJ
    CANCER AND METASTASIS REVIEWS, 1994, 13 (01) : 67 - 89
  • [4] Membrane association and targeting of prenylated Ras-like GTPases
    Seabra, MC
    CELLULAR SIGNALLING, 1998, 10 (03) : 167 - 172
  • [5] Activation and inactivation of Ras-like GTPases by bacterial cytotoxins
    von Eichel-Streiber, C
    Weidmann, M
    Giry, M
    Moos, M
    METHODS IN MICROBIOLOGY, VOL 27: BACTERIAL PATHOGENESIS, 1998, 27 : 509 - 525
  • [6] Evolution of the Rho family of Ras-like GTPases in eukaryotes
    Boureux, Anthony
    Vignal, Emmanuel
    Faure, Sandrine
    Fort, Philippe
    MOLECULAR BIOLOGY AND EVOLUTION, 2007, 24 (01) : 203 - 216
  • [7] SIGNAL-TRANSDUCTION PATHWAYS INVOLVING RAS
    WIESMULLER, L
    WITTINGHOFER, F
    CELLULAR SIGNALLING, 1994, 6 (03) : 247 - 267
  • [8] CONTROL OF SIGNAL-TRANSDUCTION AND MORPHOGENESIS BY RAS
    HUGHES, DA
    SEMINARS IN CELL BIOLOGY, 1995, 6 (02): : 89 - 94
  • [9] SIGNAL-TRANSDUCTION - THE HUNT FOR RAS TARGETS
    FEIG, LA
    SCHAFFHAUSEN, B
    NATURE, 1994, 370 (6490) : 508 - 509
  • [10] Rap1, a mercenary among the Ras-like GTPases
    Frische, E. W.
    Zwartkruis, F. J. T.
    DEVELOPMENTAL BIOLOGY, 2010, 340 (01) : 1 - 9
12345