EFFECTS OF KW-3902, AN ADENOSINE A(1)-RECEPTOR ANTAGONIST, ON ASCITES VOLUME IN PUROMYCIN AMINONUCLEOSIDE (PAN)-INDUCED NEPHROTIC RATS

We investigated the effects of KW-3902 (8-(noradamantan-3-yl)-1,3-dipropylxanthine), a potent adenosine A(1)-receptor antagonist, on the nephrotic edema induced by puromycin aminonucleoside (PAN; 100 mg/kg, i.v.) in rats. The treatment with PAN decreased urine volume and urinary excretions of sodium and potassium, resulting in the ascites formation in 7 days. In rats with the nephrosis, KW-3902 (0.01-1 mg/kg/day for 3 days, p.o.) showed diuretic effects and reduced the volume of ascites, as was the case with furosemide (30 mg/kg/day) and trichlormethiazide (1 mg/kg/day). These results suggest that even in the nephrotic state, the adenosine Al-receptor antagonist can be an effective diuretic to ameliorate edema.