IMMUNOHISTOCHEMICAL CHARACTERISTICS OF MONOCYTOID B-CELL LYMPHOMA, MANTLE ZONE LYMPHOMA, SMALL LYMPHOCYTIC LYMPHOMA (OR B-CHRONIC LYMPHOCYTIC-LEUKEMIA), AND HAIRY-CELL LEUKEMIA

被引：0
作者：
OKA, K [1 ]
MORI, N [1 ]
YATABE, Y [1 ]
机构：
[1] NAGOYA UNIV,SCH MED,DEPT PATHOL,NAGOYA,AICHI 466,JAPAN
来源：
ACTA HAEMATOLOGICA | 1993年 / 90卷 / 02期
关键词：
CHRONIC LYMPHOCYTIC LEUKEMIA; HAIRY CELL LEUKEMIA; IMMUNOHISTOCHEMISTRY; LOW GRADE B CELL LYMPHOMAS; MANTLE ZONE LYMPHOMA; MONOCYTOID B CELL LYMPHOMA; SMALL LYMPHOCYTIC LYMPHOMA;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Biopsy specimens obtained from 2 patients with monocytoid B cell lymphoma, 7 with mantle zone lymphoma, 7 with small lymphocytic lymphoma or B chronic lymphocytic leukemia, and 6 with hairy cell leukemia were investigated using an immunohistochemical method to detect their immunophenotypic characteristics. Periodate-lysine-paraformaldehyde-fixed frozen biopsies from the lymph node, peripheral blood, bone marrow, spleen, tonsil, lung, and stomach were studied. Monocytoid B cell lymphoma exhibited the immunophenotype of surface(s) IgD-/DRC-1-/Leu-1(CD5)-/Leu-MS(CD11c)-,+/- on the neoplastic cells or neoplastic lesions, mantle zone lymphoma exhibited that of sIgD+/DRC-1++/Leu-1-,+/Leu-M5-, small lymphocytic lymphoma or B chronic lymphocytic leukemia that of Leu-1+/sIgD-,+/DRC-1->+/Leu-M5-, and hairy cell leukemia that of Leu-M5++/sIgD->>+/Leu-1->>+/DRC-1-. We therefore suggest that these four types of lymphomas can be differentiated by a combination of anti-sIgD, DRC-1, Leu-1, and Leu-M5 monoclonal antibodies based on their immunophenotypic characteristics.
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页码：84 / 89
页数：6
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