IMMUNOHISTOCHEMICAL CHARACTERISTICS OF MONOCYTOID B-CELL LYMPHOMA, MANTLE ZONE LYMPHOMA, SMALL LYMPHOCYTIC LYMPHOMA (OR B-CHRONIC LYMPHOCYTIC-LEUKEMIA), AND HAIRY-CELL LEUKEMIA

被引：0

作者：

OKA, K ^{[1
]}

MORI, N ^{[1
]}

YATABE, Y ^{[1
]}

机构：

[1] NAGOYA UNIV,SCH MED,DEPT PATHOL,NAGOYA,AICHI 466,JAPAN

来源：

ACTA HAEMATOLOGICA | 1993年 / 90卷 / 02期

关键词：

CHRONIC LYMPHOCYTIC LEUKEMIA; HAIRY CELL LEUKEMIA; IMMUNOHISTOCHEMISTRY; LOW GRADE B CELL LYMPHOMAS; MANTLE ZONE LYMPHOMA; MONOCYTOID B CELL LYMPHOMA; SMALL LYMPHOCYTIC LYMPHOMA;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Biopsy specimens obtained from 2 patients with monocytoid B cell lymphoma, 7 with mantle zone lymphoma, 7 with small lymphocytic lymphoma or B chronic lymphocytic leukemia, and 6 with hairy cell leukemia were investigated using an immunohistochemical method to detect their immunophenotypic characteristics. Periodate-lysine-paraformaldehyde-fixed frozen biopsies from the lymph node, peripheral blood, bone marrow, spleen, tonsil, lung, and stomach were studied. Monocytoid B cell lymphoma exhibited the immunophenotype of surface(s) IgD-/DRC-1-/Leu-1(CD5)-/Leu-MS(CD11c)-,+/- on the neoplastic cells or neoplastic lesions, mantle zone lymphoma exhibited that of sIgD+/DRC-1++/Leu-1-,+/Leu-M5-, small lymphocytic lymphoma or B chronic lymphocytic leukemia that of Leu-1+/sIgD-,+/DRC-1->+/Leu-M5-, and hairy cell leukemia that of Leu-M5++/sIgD->>+/Leu-1->>+/DRC-1-. We therefore suggest that these four types of lymphomas can be differentiated by a combination of anti-sIgD, DRC-1, Leu-1, and Leu-M5 monoclonal antibodies based on their immunophenotypic characteristics.

引用

页码：84 / 89

页数：6

共 38 条

[1]

[Anonymous], 1982, CANCER, V49, P2112

[2] MANTLE CELL LYMPHOMA - A PROPOSAL FOR UNIFICATION OF MORPHOLOGICAL, IMMUNOLOGICAL, AND MOLECULAR-DATA [J].