CYTOTOXIC ACTIVITY OF LUVUNGA SCANDENS AGAINST HUMAN CANCER CELL LINES

被引：0
作者：
Al-Zikria, Putri Nur Hidayah [1 ]
Taher, Muhammad [1 ]
Susanti, Deny [2 ]
Ichwan, Solachuddin Jauhari Arief [3 ]
机构：
[1] Int Islamic Univ Malaysia, Kulliyyah Pharm, Dept Pharmaceut Technol, Kuantan 25200, Pahang, Malaysia
[2] Int Islamic Univ Malaysia, Kulliyyah Pharm, Dept Chem, Kuantan 25200, Pahang, Malaysia
[3] Int Islamic Univ Malaysia, Kulliyyah Dent, Kuantan 25200, Pahang, Malaysia
来源：
JURNAL TEKNOLOGI | 2016年 / 78卷 / 10期
关键词：
Luvunga scandens; cytotoxic activity; MTT; MCF-7; A549;
D O I：
暂无
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Luvunga scandens belongs to the family of Rutaceae which usually inhabit tropical and moist environment. This plant is known as 'Mengkurat Jakun' among locals and used traditionally to treat fever and fatigue via decoction. The aim of this study was to investigate the cytotoxic activity of the leaves and stems extracts of L. scandens extract. Extracts of the leaves and stems were obtained from sequential extraction procedures by various organic solvents. All extracts were subjected to cytotoxic study by 3-(4, 5-dimethylthaizol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. In in vitro cytotoxicity assay, all L. scandens extracts exhibited cytotoxicity against human breast adenocarcinoma (MCF-7) and human lung adenocarcinoma (A549) cell lines. The IC50 values of dichloromethane and methanol extracts from the leaves of L. scandens against MCF-7 cell line were 62.5 mu g/mL and 88.0 mu g/mL, respectively, whereas IC50 of methanol extract from stem was 81.0 mu g/mL. All extracts were less active against A549 cell line where IC50 value were not be determined. The present findings revealed the potential of L. scandens as a cytotoxic agent against MCF-7 cell line. However, further studies should be planned to evaluate role of the plant in cytotoxic activity. (C) 2016 Penerbit UTM Press. All rights reserved
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页码：153 / 157
页数：5
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