CYTOTOXIC ACTIVITY OF LUVUNGA SCANDENS AGAINST HUMAN CANCER CELL LINES

被引:0
作者
Al-Zikria, Putri Nur Hidayah [1 ]
Taher, Muhammad [1 ]
Susanti, Deny [2 ]
Ichwan, Solachuddin Jauhari Arief [3 ]
机构
[1] Int Islamic Univ Malaysia, Kulliyyah Pharm, Dept Pharmaceut Technol, Kuantan 25200, Pahang, Malaysia
[2] Int Islamic Univ Malaysia, Kulliyyah Pharm, Dept Chem, Kuantan 25200, Pahang, Malaysia
[3] Int Islamic Univ Malaysia, Kulliyyah Dent, Kuantan 25200, Pahang, Malaysia
来源
JURNAL TEKNOLOGI | 2016年 / 78卷 / 10期
关键词
Luvunga scandens; cytotoxic activity; MTT; MCF-7; A549;
D O I
暂无
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Luvunga scandens belongs to the family of Rutaceae which usually inhabit tropical and moist environment. This plant is known as 'Mengkurat Jakun' among locals and used traditionally to treat fever and fatigue via decoction. The aim of this study was to investigate the cytotoxic activity of the leaves and stems extracts of L. scandens extract. Extracts of the leaves and stems were obtained from sequential extraction procedures by various organic solvents. All extracts were subjected to cytotoxic study by 3-(4, 5-dimethylthaizol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. In in vitro cytotoxicity assay, all L. scandens extracts exhibited cytotoxicity against human breast adenocarcinoma (MCF-7) and human lung adenocarcinoma (A549) cell lines. The IC50 values of dichloromethane and methanol extracts from the leaves of L. scandens against MCF-7 cell line were 62.5 mu g/mL and 88.0 mu g/mL, respectively, whereas IC50 of methanol extract from stem was 81.0 mu g/mL. All extracts were less active against A549 cell line where IC50 value were not be determined. The present findings revealed the potential of L. scandens as a cytotoxic agent against MCF-7 cell line. However, further studies should be planned to evaluate role of the plant in cytotoxic activity. (C) 2016 Penerbit UTM Press. All rights reserved
引用
收藏
页码:153 / 157
页数:5
相关论文
共 50 条
  • [21] Cytotoxic activity of low molecular weight polyphenols against human oral tumor cell lines
    Fukai, T
    Sakagami, H
    Toguchi, M
    Takayama, F
    Iwakura, I
    Atsumi, T
    Ueha, T
    Nakashima, H
    Nomura, T
    [J]. ANTICANCER RESEARCH, 2000, 20 (04) : 2525 - 2536
  • [22] Cytotoxic activity properties of a benzimidazolium salt against lung, liver, and colon cancer cell lines
    Akkoc, Senem
    [J]. JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2024, 101 (11)
  • [23] Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines
    de Mesquita, Mariana Laundry
    de Paula, Jose Elias
    Pessoa, Claudia
    de Moraes, Manoel Odorico
    Costa-Lotufo, Leticia Veras
    Grougnet, Raphael
    Michel, Sylvie
    Tillequin, Francois
    Espindola, Laila Salmen
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 2009, 123 (03) : 439 - 445
  • [24] An in vitro evaluation of the cytotoxic potential of medicinal mushrooms against human breast cancer cell lines
    Topalovic, Dijana
    Zivkovic, Lada
    Borozan, Suncica
    Santibanez, Juan F.
    Spremo-Potparevic, Biljana
    [J]. ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY, 2024, 75 (04): : 297 - 302
  • [25] Cytotoxic activity of 5-benzoylimidazole and related compounds against human oral tumor cell lines
    Terasawa, K
    Sugita, Y
    Yokoe, I
    Fujisawa, S
    Sakagami, H
    [J]. ANTICANCER RESEARCH, 2001, 21 (2A) : 1081 - 1086
  • [26] Cytotoxic Activity of Christia vespertilionis Root and Leaf Extracts and Fractions against Breast Cancer Cell Lines
    Lee, Joanna Jinling
    Yazan, Latifah Saiful
    Kassim, Nur Kartinee
    Abdullah, Che Azurahanim Che
    Esa, Nurulaidah
    Lim, Pei Cee
    Tan, Dai Chuan
    [J]. MOLECULES, 2020, 25 (11):
  • [27] Malabar spinach potentiates cytotoxic activity through apoptosis in human breast cancer cell lines
    Shrirang, Hogale Mangesh
    Kariyil, Bibu John
    John, Reni
    Menon, K. Priyanka
    [J]. PLANT SCIENCE TODAY, 2024, 11 (03): : 183 - 190
  • [28] Synthesis and Cytotoxic Activity Evaluation of Novel Arylpiperazine Derivatives on Human Prostate Cancer Cell Lines
    Chen, Hong
    Liang, Xue
    Xu, Fang
    Xu, Bingbing
    He, Xuelan
    Huang, Biyun
    Yuan, Mu
    [J]. MOLECULES, 2014, 19 (08) : 12048 - 12064
  • [29] Cytotoxic and Apoptosis-Inducing Activities of Steviol and Isosteviol Derivatives against Human Cancer Cell Lines
    Ukiya, Motohiko
    Sawada, Shingo
    Kikuchi, Takashi
    Kushi, Yasunori
    Fukatsu, Makoto
    Akihisa, Toshihiro
    [J]. CHEMISTRY & BIODIVERSITY, 2013, 10 (02) : 177 - 188
  • [30] Cytotoxic activity and anti-cancer potential of Ontario grown onion extracts against breast cancer cell lines
    Fragis, Meghan
    Murayyan, Abdulmonem I.
    Neethirajan, Suresh
    [J]. FUNCTIONAL FOODS IN HEALTH AND DISEASE, 2018, 8 (03): : 159 - 173