INHIBITORY-ACTION OF CALCITONIN GENE-RELATED PEPTIDE (CGRP) IN THE MOUSE COLON

被引：4

作者：

CADIEUX, A ^{[1
]}

POMERLEAU, F ^{[1
]}

STPIERRE, S ^{[1
]}

FOURNIER, A ^{[1
]}

机构：

[1] UNIV QUEBEC,INST NATL RECH SCI SANTE,MONTREAL H1N 3M5,QUEBEC,CANADA

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1990年 / 42卷 / 07期

关键词：

D O I：

10.1111/j.2042-7158.1990.tb06612.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Abstract— The effect and mechanism of action of calcitonin gene‐ related peptide (CGRP) have been investigated on the mouse distal colon. CGRP caused a concentration‐dependent relaxation which was not blocked by classical pharmacological antagonists. The response pattern was characterized by a relatively rapid onset and long sustained duration. The results suggest that CGRP itself may contribute to regulating the muscular tone of the mouse colon. 1990 Royal Pharmaceutical Society of Great Britain

引用

页码：520 / 521

页数：2

共 16 条

[1] CALCITONIN GENE-RELATED PEPTIDE IS A POTENT RELAXANT OF INTESTINAL MUSCLE [J].

BARTHO, L ;

LEMBECK, F ;

HOLZER, P .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 135 (03) :449-451

[2]

BURNSTOCK G, 1986, ARCH INT PHARMACOD T, V280, P1

[3] LOCALIZATION OF CALCITONIN GENE-RELATED PEPTIDE-LIKE IMMUNOREACTIVITY IN NEURONS OF THE RAT GASTROINTESTINAL-TRACT [J].

CLAGUE, JR ;

STERNINI, C ;

BRECHA, NC .

NEUROSCIENCE LETTERS, 1985, 56 (01) :63-68

[4] PEPTIDES AND THE HUMAN-COLON - AN INVITRO PHARMACOLOGICAL STUDY [J].

COUTURE, R ;

MIZRAHI, J ;

REGOLI, D ;

DEVROEDE, G .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1981, 59 (09) :957-964

[5] EFFECTS OF NEUROTENSIN ON THE ISOLATED MOUSE DISTAL COLON [J].

FONTAINE, J ;

LEBRUN, P .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 107 (02) :141-147

[6] ADRENOCEPTORS AND REGULATION OF INTESTINAL TONE IN THE ISOLATED COLON OF THE MOUSE [J].

FONTAINE, J ;

GRIVEGNEE, A ;

REUSE, J .

BRITISH JOURNAL OF PHARMACOLOGY, 1984, 81 (02) :231-243

[7] CONTRACTOR RESPONSES OF THE ISOLATED COLON OF THE MOUSE TO MORPHINE AND SOME OPIOID-PEPTIDES [J].

FONTAINE, J ;

REUSE, J .

BRITISH JOURNAL OF PHARMACOLOGY, 1985, 85 (04) :861-867

[8] EVIDENCE AGAINST VIP AS THE INHIBITORY TRANSMITTER IN NONADRENERGIC, NONCHOLINERGIC NERVES SUPPLYING THE LONGITUDINAL MUSCLE OF THE MOUSE COLON [J].

FONTAINE, J ;

GRIVEGNEE, AR ;

ROBBERECHT, P .

BRITISH JOURNAL OF PHARMACOLOGY, 1986, 89 (03) :599-602

[9] CO-LOCALIZATION OF CALCITONIN GENE-RELATED PEPTIDE-LIKE IMMUNOREACTIVITY WITH SUBSTANCE-P IN CUTANEOUS, VASCULAR AND VISCERAL SENSORY NEURONS OF GUINEA-PIGS [J].

GIBBINS, IL ;

FURNESS, JB ;

COSTA, M ;

MACINTYRE, I ;

HILLYARD, CJ ;

GIRGIS, S .

NEUROSCIENCE LETTERS, 1985, 57 (02) :125-130

[10]

KATSOULIS S, 1989, EUR J PHARMACOL, V161, P129

← 1 2 →