BRAIN SYNAPTOSOMAL CA-2+ UPTAKE - COMPARISON OF SPRAGUE-DAWLEY, WISTAR-KYOTO AND SPONTANEOUSLY HYPERTENSIVE RATS

被引：10
作者：
HONDA, H [1 ]
SHIBUYA, T [1 ]
SALAFSKY, B [1 ]
机构：
[1] TOKYO MED COLL, DEPT PHARMACOL, TOKYO 160, JAPAN
来源：
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1990年 / 95卷 / 03期
关键词：
D O I：
10.1016/0305-0491(90)90020-T
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1. 1. K+-stimulated 45Ca2+ uptake by synaptosomes was measured with respect to the strain differences between Sprague-Dawley (SD), Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). 2. 2. 45Ca2+ uptake by synaptosomes isolated from cerebral cortex of SD, WKY and SHR was measured at 15, 30, 60, 120 and 240 sec time periods. 3. 3. The sequence of both the magnitude and rate of resting and depolarization-dependent 45Ca2+ uptake was SHR > WKY > SD. 4. 4. The fastest rates of resting and depolarization-dependent 45Ca2+ uptake occurred in each rat during the first 15 sec and uptake rates dropped off quickly in both resting and depolarization states. 5. 5. At 15 sec, there were significant differences between SHR and WKY, while there were no significant differences between WKY and SD. 6. 6. The results suggest that an important alteration in Ca2+ channel characteristics may occur in SHR brain synaptosomes. © 1990.
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页码：555 / 558
页数：4
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