HUMAN GENE-THERAPY

被引：740
作者：
ANDERSON, WF
机构：
来源：
SCIENCE | 1992年 / 256卷 / 5058期
关键词：
D O I：
10.1126/science.1589762
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Human gene therapy is a procedure that is being used in an attempt to treat genetic and other diseases. Eleven clinical protocols are under way at the present time, each with scientific and clinical objectives. Human genetic engineering raises unique safety, social, and ethical concerns.
引用
收藏
页码：808 / 813
页数：6
相关论文
共 92 条
[71]   EXPERIENCE WITH THE USE OF HIGH-DOSE INTERLEUKIN-2 IN THE TREATMENT OF 652 CANCER-PATIENTS [J].
ROSENBERG, SA ;
LOTZE, MT ;
YANG, JC ;
AEBERSOLD, PM ;
LINEHAN, WM ;
SEIPP, CA ;
WHITE, DE .
ANNALS OF SURGERY, 1989, 210 (04) :474-485
[72]   USE OF TUMOR-INFILTRATING LYMPHOCYTES AND INTERLEUKIN-2 IN THE IMMUNOTHERAPY OF PATIENTS WITH METASTATIC MELANOMA - A PRELIMINARY-REPORT [J].
ROSENBERG, SA ;
PACKARD, BS ;
AEBERSOLD, PM ;
SOLOMON, D ;
TOPALIAN, SL ;
TOY, ST ;
SIMON, P ;
LOTZE, MT ;
YANG, JC ;
SEIPP, CA ;
SIMPSON, C ;
CARTER, C ;
BOCK, S ;
SCHWARTZENTRUBER, D ;
WEI, JP ;
WHITE, DE .
NEW ENGLAND JOURNAL OF MEDICINE, 1988, 319 (25) :1676-1680
[73]   A PHASE-I TRIAL OF HIGH-DOSE CARBOPLATIN AND ETOPOSIDE WITH AUTOLOGOUS MARROW SUPPORT FOR TREATMENT OF STAGE-D NEUROBLASTOMA IN 1ST REMISSION - USE OF MARKER GENES TO INVESTIGATE THE BIOLOGY OF MARROW RECONSTITUTION AND THE MECHANISM OF RELAPSE [J].
SANTANA, VM ;
BRENNER, MK ;
IHLE, J ;
KRANCE, R ;
RIBEIRO, R ;
HURWITZ, C ;
MAHMOUD, H ;
MOEN, RC ;
FRENCHANDERSON, W .
HUMAN GENE THERAPY, 1991, 2 (03) :257-272
[74]   DOES HUMAN GENE-THERAPY RAISE NEW ETHICAL QUESTIONS [J].
TAUER, CA .
HUMAN GENE THERAPY, 1990, 1 (04) :411-418
[75]   OVERVIEW OF BIOLOGICAL EFFECTS OF ADDITION OF DNA-MOLECULES TO CELLS [J].
TEMIN, HM .
JOURNAL OF MEDICAL VIROLOGY, 1990, 31 (01) :13-17
[76]   SAFETY CONSIDERATIONS IN SOMATIC GENE-THERAPY OF HUMAN-DISEASE WITH RETROVIRUS VECTORS [J].
TEMIN, HM .
HUMAN GENE THERAPY, 1990, 1 (02) :111-123
[77]  
VANBEUSECHEM VW, IN PRESS P NATL ACAD
[78]   HUMAN GENE-THERAPY - ETHICS AND PUBLIC-POLICY [J].
WALTERS, L .
HUMAN GENE THERAPY, 1991, 2 (02) :115-122
[79]   THE ETHICS OF HUMAN-GENE THERAPY [J].
WALTERS, L .
NATURE, 1986, 320 (6059) :225-227
[80]   GENE-THERAPY [J].
WEATHERALL, DJ .
BRITISH MEDICAL JOURNAL, 1989, 298 (6675) :691-693
12345678910