NEW CYTOTOXIC BETA-CARBOLINE ALKALOIDS FROM THE MARINE BRYOZOAN, CRIBRICELLINA-CRIBRARIA

被引：78

作者：

PRINSEP, MR

BLUNT, JW

MUNRO, MHG

机构：

[1] Department of Chemistry, University of Canterbury, Christchurch

来源：

JOURNAL OF NATURAL PRODUCTS | 1991年 / 54卷 / 04期

关键词：

D O I：

10.1021/np50076a023

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioactivity-directed separations led to the isolation of the new alkaloid, 1-vinyl-8-hydroxy-beta-carboline [1], as the major cytotoxic component of the marine bryozoan Cribricellina cribraria. Another new beta-carboline alkaloid 2 with the novel sulfone structure was isolated, together with a number of known beta-carboline compounds. Cytotoxicity and antimicrobial effects are reported for these compounds and for other synthesized beta-carbolines.

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页码：1068 / 1076

页数：9

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