DEFEROXAMINE AND EFLORNITHINE (DL-ALPHA-DIFLUOROMETHYLORNITHINE) IN A RAT MODEL OF PNEUMOCYSTIS-CARINII PNEUMONIA

被引：41

作者：

CLARKSON, AB ^{[1
]}

SARIC, M ^{[1
]}

GRADY, RW ^{[1
]}

机构：

[1] CORNELL UNIV,MED CTR,COLL MED,DEPT PEDIAT,NEW YORK,NY 10021

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 09期

关键词：

D O I：

10.1128/AAC.34.9.1833

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The iron chelator deferoxamine and the polyamine biosynthesis inhibitor eflornithine (DL-α-difluoromethylornithine) were examined for anti-Pneumocystis carinii activity in the rat model of P. carinii pneumonia. The activity of deferoxamine at 250, 500, and 1,000 mg/kg given intraperitoneally provides evidence that iron chelation is a promising novel approach to P. Carinii chemotherapy. Results with eflornithine at 2, 3, and 4% in drinking water confirm and extend previously reported activity in the rat model.

引用

页码：1833 / 1835

页数：3

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