Update on management of acute respiratory distress syndrome

被引:1
作者
Fong, Ka-man [1 ]
Au, Shek-yin [1 ]
Chan, Ka-lee Lily [1 ]
Ng, Wing-yiu George [1 ]
机构
[1] Queen Elizabeth Hosp, Intens Care Unit, Hong Kong, Hong Kong, Peoples R China
关键词
acute respiratory distress syndrome; respiratory failure; lung protective strategies; mechanical ventilation; ECMO; prone ventilation; neuromuscular blockade; high flow nasal cannula;
D O I
10.3934/medsci.2018.2.145
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Acute respiratory distress syndrome (ARDS) is a frequent and life-threatening condition in intensive care units (ICUs). Management of ARDS remains challenging despite years of research. Morbidity and mortality are not only caused by the syndrome itself but can also be the result of ventilator-induced lung injury. In this article, an update on ARDS management including ventilator strategies, rescue therapies, pharmacological treatments, ICU supportive care, and rehabilitation is proposed. While lung protective ventilation remains the standard option for patients with ARDS, neuromuscular blockade and prone positioning are gaining support after successful trials. Helmet non-invasive ventilation and high-flow nasal cannula might be useful for mild-to-moderate ARDS. Extracorporeal membrane oxygenation and carbon dioxide removal are not recommended in standard practice although they might be useful in severe ARDS.
引用
收藏
页码:145 / 161
页数:17
相关论文
共 98 条
[1]   Driving Pressure and Survival in the Acute Respiratory Distress Syndrome [J].
Amato, Marcelo B. P. ;
Meade, Maureen O. ;
Slutsky, Arthur S. ;
Brochard, Laurent ;
Costa, Eduardo L. V. ;
Schoenfeld, David A. ;
Stewart, Thomas E. ;
Briel, Matthias ;
Talmor, Daniel ;
Mercat, Alain ;
Richard, Jean-Christophe M. ;
Carvalho, Carlos R. R. ;
Brower, Roy G. .
NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (08) :747-755
[2]   Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome [J].
Amato, MBP ;
Barbas, CSV ;
Medeiros, DM ;
Magaldi, RB ;
Schettino, GDP ;
Lorenzi, G ;
Kairalla, RA ;
Deheinzelin, D ;
Munoz, C ;
Oliveira, R ;
Takagaki, TY ;
Carvalho, CRR .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (06) :347-354
[3]   Early activity is feasible and safe in respiratory failure patients [J].
Bailey, Polly ;
Thomsen, George E. ;
Spuhler, Vicki J. ;
Blair, Robert ;
Jewkes, James ;
Bezdjian, Louise ;
Veale, Kristy ;
Rodriquez, Larissa ;
Hopkins, Ramona O. .
CRITICAL CARE MEDICINE, 2007, 35 (01) :139-145
[4]  
Barnes T., 2017, CHEST
[5]   The rise and fall of β-agonists in the treatment of ARDS [J].
Bassford, Christopher R. ;
Thickett, David R. ;
Perkins, Gavin D. .
CRITICAL CARE, 2012, 16 (02)
[6]   Focus on ECMO and - ECCO2R in ARDS patients [J].
Bein, Thomas ;
Aubron, Cecile ;
Papazian, Laurent .
INTENSIVE CARE MEDICINE, 2017, 43 (09) :1424-1426
[7]   Lower tidal volume strategy (≈ 3 ml/kg) combined with extracorporeal CO2 removal versus 'conventional' protective ventilation (6 ml/kg) in severe ARDS [J].
Bein, Thomas ;
Weber-Carstens, Steffen ;
Goldmann, Anton ;
Mueller, Thomas ;
Staudinger, Thomas ;
Brederlau, Joerg ;
Muellenbach, Ralf ;
Dembinski, Rolf ;
Graf, Bernhard M. ;
Wewalka, Marlene ;
Philipp, Alois ;
Wernecke, Klaus-Dieter ;
Lubnow, Matthias ;
Slutsky, Arthur S. .
INTENSIVE CARE MEDICINE, 2013, 39 (05) :847-856
[8]   Noninvasive Ventilation of Patients with Acute Respiratory Distress Syndrome Insights from the LUNG SAFE Study [J].
Bellani, Giacomo ;
Laffey, John G. ;
Tai Pham ;
Madotto, Fabiana ;
Fan, Eddy ;
Brochard, Laurent ;
Esteban, Andres ;
Gattinoni, Luciano ;
Bunnbasirevic, Vesna ;
Piquilloud, Lise ;
van Haren, Frank ;
Larsson, Anders ;
McAuley, Daniel F. ;
Bauer, Philippe R. ;
Arabi, Yaseen M. ;
Ranieri, Marco ;
Antonelli, Massimo ;
Rubenfeld, Gordon D. ;
Thompson, B. Taylor ;
Wrigge, Hermann ;
Slutsky, Arthur S. ;
Pesenti, Antonio .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 195 (01) :67-77
[9]   Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries [J].
Bellani, Giacomo ;
Laffey, John G. ;
Pham, Tai ;
Fan, Eddy ;
Brochard, Laurent ;
Esteban, Andres ;
Gattinoni, Luciano ;
van Haren, Frank ;
Larsson, Anders ;
McAuley, Daniel F. ;
Ranieri, Marco ;
Rubenfeld, Gordon ;
Thompson, B. Taylor ;
Wrigge, Hermann ;
Slutsky, Arthur S. ;
Pesenti, Antonio .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2016, 315 (08) :788-800
[10]   THE AMERICAN-EUROPEAN CONSENSUS CONFERENCE ON ARDS - DEFINITIONS, MECHANISMS, RELEVANT OUTCOMES, AND CLINICAL-TRIAL COORDINATION [J].
BERNARD, GR ;
ARTIGAS, A ;
BRIGHAM, KL ;
CARLET, J ;
FALKE, K ;
HUDSON, L ;
LAMY, M ;
LEGALL, JR ;
MORRIS, A ;
SPRAGG, R ;
COCHIN, B ;
LANKEN, PN ;
LEEPER, KV ;
MARINI, J ;
MURRAY, JF ;
OPPENHEIMER, L ;
PESENTI, A ;
REID, L ;
RINALDO, J ;
VILLAR, J ;
VANASBECK, BS ;
DHAINAUT, JF ;
MANCEBO, J ;
MATTHAY, M ;
MEYRICK, B ;
PAYEN, D ;
PERRET, C ;
FOWLER, AA ;
SCHALLER, MD ;
HUDSON, LD ;
HYERS, T ;
KNAUS, W ;
MATTHAY, R ;
PINSKY, M ;
BONE, RC ;
BOSKEN, C ;
JOHANSON, WG ;
LEWANDOWSKI, K ;
REPINE, J ;
RODRIGUEZROISIN, R ;
ROUSSOS, C ;
ANTONELLI, MA ;
BELOUCIF, S ;
BIHARI, D ;
BURCHARDI, H ;
LEMAIRE, F ;
MONTRAVERS, P ;
PETTY, TL ;
ROBOTHAM, J ;
ZAPOL, W .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1994, 149 (03) :818-824