BUILDING UNITS OF OLIGOSACCHARIDES .103. SYNTHESIS OF MODIFIED DERIVATIVES OF THE DISACCHARIDE BETA-D-GAL-(1-]3)-ALPHA-D-GALNAC FOR THE EXAMINATION OF SUBSTRATE SPECIFICITIES OF CORE 2-BETA-6-GLCNAC-TRANSFERASE AND ALPHA-3-SIALYLTRANSFERASE INVOLVED IN THE BIOSYNTHESIS OF 0-GLYCOPROTEINS

被引：0

作者：

PAULSEN, H

RUTZ, V

BROCKHAUSEN, I

机构：

[1] UNIV TORONTO,DEPT BIOCHEM,TORONTO M5G 1X8,ONTARIO,CANADA

[2] HOSP SICK CHILDREN,RES INST,TORONTO M5G 1X8,ONTARIO,CANADA

来源：

LIEBIGS ANNALEN DER CHEMIE | 1992年 / 07期

关键词：

CARBOHYDRATES; OLIGOSACCHARIDES; GLYCOSYLTRANSFERASES; O-GLYCOPROTEINS; ENZYMES;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Derivatives of benzyl beta-D-galactopyranosyl-(1 --> 3)-2-acetamido-2-deoxy-alpha-D-galactopyranoside have been synthesized. The 6'-, 4'- and 3'-OH group of the galactose moiety as well as the 6- and 4-OH and the 2-acetamido group of the 2-acetamido-2-deoxy-D-galactose moiety have been selectively substituted by the corresponding deoxy function. The compounds are useful in studies of the substrate specificities of the core 2-beta-6-GlcNAc-transferase and the alpha-3-sialyltransferase involved in the biosynthesis of O-glycoproteins.

引用

页码：747 / 758

页数：12

共 2 条

[1] BUILDING UNITS OF OLIGOSACCHARIDES .102. SYNTHESIS OF MODIFIED DERIVATIVES OF 2-ACETAMIDO-2-DEOXY-D-GALACTOSE FOR THE EXAMINATION OF SUBSTRATE SPECIFICITIES OF CORE 1-BETA-3-GAL-TRANSFERASE AND CORE 3-BETA-3-GLCNAC-TRANSFERASE INVOLVED IN THE BIOSYNTHESIS OF O-GLYCOPROTEINS
PAULSEN, H
RUTZ, V
BROCKHAUSEN, I
LIEBIGS ANNALEN DER CHEMIE, 1992, (07): : 735 - 745
[2] BUILDING UNITS OF OLIGOSACCHARIDES .105. SYNTHESIS OF THE PENTASACCHARIDE L-ALPHA-D-HEP-(1-]3)-L-ALPHA-D-HEP-(1-]5)-ALPHA-KDO-(2-]6)-BETA-D-GLCNHM-(1-]6)-D-GLCNHM OF THE LINEAR CORE AND LIPOID A STRUCTURE OF LIPOPOLYSACCHARIDES
PAULSEN, H
HOFFGEN, EC
LIEBIGS ANNALEN DER CHEMIE, 1993, (05): : 531 - 541

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