SUBSTANCE-P OPENS CATION CHANNELS AND CLOSES POTASSIUM CHANNELS IN RAT LOCUS-CERULEUS NEURONS

被引：122

作者：

SHEN, KZ ^{[1
]}

NORTH, RA ^{[1
]}

机构：

[1] OREGON HLTH SCI UNIV, VOLLUM INST, PORTLAND, OR 97201 USA

来源：

NEUROSCIENCE | 1992年 / 50卷 / 02期

关键词：

D O I：

10.1016/0306-4522(92)90428-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Whole-cell recordings were made from neurons of the rat locus coeruleus in a tissue slice removed from rat brain. Substance P caused an inward current in cells voltage-clamped at -60 mV. The effect of substance P was concentration-dependent (30 nM-3 muM) and was mimicked by similar concentrations of substance K and neuromedin K. The inward current resulted predominately from an increase in membrane cation conductance; in potassium-free solutions it reversed polarity at about 12 mV. Substance P also reduced the conductance of an inwardly rectifying potassium current; this action was studied with low external sodium concentration. It is concluded that substance P excites rat locus coeruleus neurons by activating an intracellular transduction pathway leading to both cation conductance increase and potassium conductance decrease.

引用

页码：345 / 353

页数：9

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