PROTEOLYTIC CLEAVAGE OF THE ALZHEIMERS-DISEASE AMYLOID A4 PRECURSOR PROTEIN

被引：67

作者：

ISHIURA, S

机构：

[1] National Institute of Neuroscience, Ncnp, Tokyo

来源：

JOURNAL OF NEUROCHEMISTRY | 1991年 / 56卷 / 02期

关键词：

ALZHEIMERS DISEASE; AMYLOID A4 PROTEIN; PROTEINASES; PROCESSING; MULTICATALYTIC PROTEINASE; PROLYL ENDOPEPTIDASE;

D O I：

10.1111/j.1471-4159.1991.tb08160.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Amyloid A4 protein (beta-protein) is deposited in the brain of a patient with Alzheimer's disease (AD) as one of the main components of extracellular cerebrovascular amyloid as well as neurofibrillary tangles. It is derived from a precursor protein, and its formation has been considered to be a rate-limiting step for brain degeneration in AD. In this article, proteolytic cleavage events that can degrade amyloid precursor protein are reviewed with respect to how the topographical distribution of the proteinase and its substrates disturbs normal processing steps in AD brain.

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页码：363 / 369

页数：7

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