GP120-MEDIATED ALTERATIONS IN ASTROCYTE ION-TRANSPORT

被引：18

作者：

BENOS, DJ

HAHN, BH

SHAW, GM

BUBIEN, JK

BENVENISTE, EN

机构：

[1] UNIV ALABAMA,DEPT MED,BIRMINGHAM,AL 35294

[2] UNIV ALABAMA,DEPT CELL BIOL,BIRMINGHAM,AL 35294

来源：

ADVANCES IN NEUROIMMUNOLOGY | 1994年 / 4卷 / 03期

关键词：

D O I：

10.1016/S0960-5428(06)80254-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The pathogenesis of the acquired immunodeficiency syndrome (AIDS) dementia complex (ADC) is unknown. However, recent work indicates that neurons and astrocytes are functionally compromised by exposure to viral components or cellular factors released from HIV-1-infected macrophages/microglia. We show that exposure of primary cultured rat astrocytes to the major HIV envelope glycoprotein gp120 results in alterations of ion and solute transport that may contribute to neuronal cell injury.

引用

收藏

页码：175 / 179

页数：5

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