INCREASED CONCENTRATIONS OF APO B-CONTAINING TRIGLYCERIDE-RICH LIPOPROTEIN PARTICLES IN PATIENTS WITH CHRONIC-RENAL-FAILURE

被引：0

作者：

ATTMAN, PO ^{[1
]}

KNIGHTGIBSON, C ^{[1
]}

TAVELLA, M ^{[1
]}

SAMUELSSON, O ^{[1
]}

ALAUPOVIC, P ^{[1
]}

机构：

[1] OKLAHOMA MED RES FDN,LIPOPROT & ATHEROSCLEROSIS RES PROGRAM,OKLAHOMA CITY,OK 73104

来源：

MINERAL AND ELECTROLYTE METABOLISM | 1992年 / 18卷 / 2-5期

关键词：

APOLIPOPROTEINS; ATHEROSCLEROSIS; CHRONIC RENAL FAILURE; HEMODIALYSIS; LIPOPROTEINS;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The dyslipoproteinemia of chronic renal failure (CRF) was characterized by discrete Apo B-containing lipoprotein particles separated by sequential immunoprecipitation of VLDL, IDL and LDL with antisera to Apo E and Apo C-III. CRF patients before and during dialysis had increased concentrations of Apo B-containing lipoproteins (LP) due to increased levels of triglyceride-rich LP-B:C and LP-B:C:E particles with no significant change in the levels of cholesterol-rich LP-B. Patients on hemodialysis had lower concentrations of LP-B:C and higher concentrations of LP-B:C:E than predialytic patients. The increase of Apo B-containing lipoprotein particles in CRF may contribute to atherosclerotic vascular disease and to glomerulosclerosis and progression of renal insufficiency.

引用

页码：199 / 202

页数：4

共 19 条

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JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1992, 3 (05): : 1156 - 1162
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NEPHROLOGY DIALYSIS TRANSPLANTATION, 1992, 7 (07) : 623 - 626
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ATHEROSCLEROSIS, 1998, 138 (02) : 301 - 312
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NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 1996, 6 (04) : 203 - 210
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MINERAL AND ELECTROLYTE METABOLISM, 1992, 18 (2-5) : 196 - 198
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NEPHRON, 1993, 65 (03): : 401 - 409
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