ANTI-LYMPHOPROLIFERATIVE ACTIVITY OF BROWN ADIPOSE-TISSUE OF HIBERNATING GROUND-SQUIRRELS IS MAINLY CAUSED BY AMP

被引：19

作者：

ATANASSOV, CL

NAEGELI, HU

ZENKE, G

SCHNEIDER, C

KRAMAROVA, LI

BRONNIKOV, GE

VANREGENMORTEL, MHV

机构：

[1] CNRS,INST BIOL MOLEC & CELLULAIRE,UPR 9021,F-67084 STRASBOURG,FRANCE

[2] SANDOZ PHARMA LTD,CH-4002 BASEL,SWITZERLAND

[3] RUSSIAN ACAD SCI,INST CELL BIOPHYS,PUSHCHINO 142292,RUSSIA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1995年 / 112卷 / 01期

关键词：

HIBERNATION; BROWN FAT; IMMUNOSUPPRESSION; AMP; THYMUS;

D O I：

10.1016/0742-8413(95)00000-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A fraction with mol wt < 1 kDa was obtained from the brown fat of hibernating ground squirrels (Citellus undulatus) by means of delipidization, acid extraction, ultracentrifugation and ultrafiltration, This fraction suppressed the proliferation of mouse lymph node cells under standard mitogenic stimuli for T lymphocytes, In contrast, the fraction with mol wt < 1 kDa obtained from the brown fat of active ground squirrels in spring did not display such activity. Further HPLC purification of the biologically active fraction and chemical and structural analysis of its most potent antilymphoproliferative component revealed that this is adenosine 5'-monophosphate (AMP). These data lend support to the notion that in hibernating mammals AMP originating, at least partly, from the brown fat down-regulates the seasonally-dependent proliferation of the thymus.

引用

页码：93 / 100

页数：8

共 28 条

[1]

BENITO M, 1985, BIOL NEONATE, V48, P245, DOI 10.1159/000242177

[2]

BRONNIKOV G, 1992, J BIOL CHEM, V267, P2006

[3]

BRONNIKOV G, 1993, 1993 P S LIV COLD 3, P5

[4] EFFECT OF ADENOSINE DEAMINASE INHIBITION UPON HUMAN LYMPHOCYTE BLASTOGENESIS [J].