INTRACRANIAL DRUG IMPLANTS - AN AUTORADIOGRAPHIC ANALYSIS OF DIFFUSION

被引：44
作者：
GROSSMAN, SP
STUMPF, WE
机构：
[1] Section of Biopsychology, University of Chicago, Chicago
来源：
SCIENCE | 1969年 / 166卷 / 3911期
关键词：
D O I：
10.1126/science.166.3911.1410
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Labeled crystalline atropine, administered to the hypothalamus of rats, remained strictly localized in a sphere, 1.0 to 1.8 millimeters in diameter, during the first 3 minutes. A similar distribution obtained after 1 hour. At intermediate times, slightly elevated radioactivity, reflecting concentrations 2,000 to 10,000 times below behaviorally effective doses, was observed several millimeters from the implantation site.
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页码：1410 / +
页数：1
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