ENDURING CHANGES IN DOPAMINE RECEPTOR CELLS OF PUPS FROM DRUG ADMINISTRATION TO PREGNANT AND NURSING RATS

被引：203

作者：

ROSENGARTEN, H

FRIEDHOFF, AJ

机构：

[1] Millhauser Laboratories, Department of Psychiatry, New York University School of Medicine, New York

来源：

SCIENCE | 1979年 / 203卷 / 4385期

关键词：

D O I：

10.1126/science.570724

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A decrease in specific [3H]spiroperidol binding to rat caudate tissue and a parallel decrease in sensitivity to apomorphine in eliciting stereotyped behavior was observed in the offspring of rat mothers treated with either haloperidol or α-methyl-p-tyrosine-methyl ester during pregnancy. In contrast, evidence of increased dopamine-receptor sensitivity was observed in the pups if haloperidol was administered to their mothers postpartum during nursing rather than during pregnancy. Copyright © 1979 AAAS.

引用

页码：1133 / 1135

页数：3

共 22 条

[1]

AGRAWAL H, 1976, BIOCH BIOPHYS ACTA, V130, P511

[2] DOPAMINE-BETA-HYDROXYLASE IN RAT-BRAIN - DEVELOPMENT CHARACTERISTICS [J].