INVOLVEMENT OF CARBON-MONOXIDE IN LONG-TERM POTENTIATION IN THE DENTATE GYRUS OF ANESTHETIZED RATS

被引：18
|
作者：
IKEGAYA, Y [1 ]
SAITO, H [1 ]
MATSUKI, N [1 ]
机构：
[1] UNIV TOKYO,FAC PHARMACEUT SCI,DEPT CHEM PHARMACOL,TOKYO 113,JAPAN
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 1994年 / 64卷 / 03期
关键词：
HEME OXYGENASE INHIBITOR; ZINC PROTOPORPHYRIN IX; HIPPOCAMPUS;
D O I：
10.1254/jjp.64.225
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
To elucidate the role of carbon monoxide (CO) in hippocampal long-term potentiation (LTP), the effect of an inhibitor of heme oxygenase, which produces carbon monoxide, was investigated in the dentate gyrus of anesthetized rats. Administration of zinc protoporphyrin IX (100 nmol, i.c.v.) 30 min before the tetanic stimulation of 30 pulses at 60 Hz attenuated the intensity of LTP. However, this drug did not affect the established LTP. These results suggest that CO participates in the generation of LTP in vivo.
引用
收藏
页码：225 / 227
页数：3
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