AN IMMUNOHISTOCHEMICAL AND ELECTROPHYSIOLOGICAL STUDY ON I(SK) PROTEIN IN THE STRIA VASCULARIS OF THE GUINEA-PIG

被引：1
作者：
MORI, N [1 ]
SAKAGAMI, M [1 ]
FUKAZAWA, K [1 ]
MATSUNAGA, T [1 ]
机构：
[1] OSAKA UNIV,SCH MED,DEPT OTOLARYNGOL,OSAKA,JAPAN
来源：
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 1993年 / 250卷 / 03期
关键词：
I(SK) PROTEIN; K+ CHANNELS; STRIA VASCULARIS; MARGINAL CELLS; CLOFILIUM;
D O I：
暂无
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
The reaction product against rat I(sk) protein antibody was demonstrated on the endolymphatic surface of the marginal cell of the guinea pig, using an immunohistochemical method. Clofilium, a potassium channel blocker which has been previously found to block rat kidney I(sk) channels, decreased the endocochlear potential (EP) when applied by perilymphatic perfusion and iontophoresis into endolymph. This finding of a decreased EP supports the presence Of I(sk) protein on the endolymphatic surface of the marginal cell.
引用
收藏
页码：186 / 189
页数：4
相关论文
共 14 条
[1]  
ARENA JP, 1988, MOL PHARMACOL, V34, P60
[2]  
CASTLE NA, 1991, J PHARMACOL EXP THER, V257, P342
[3]   CLONING AND EXPRESSION OF THE DELAYED-RECTIFIER ISK CHANNEL FROM NEONATAL RAT-HEART AND DIETHYLSTILBESTROL-PRIMED RAT UTERUS [J].
FOLANDER, K ;
SMITH, JS ;
ANTANAVAGE, J ;
BENNETT, C ;
STEIN, RB ;
SWANSON, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (08) :2975-2979
[4]   ION-TRANSPORT IN GUINEA-PIG COCHLEA .1. POTASSIUM AND SODIUM-TRANSPORT [J].
KONISHI, T ;
HAMRICK, PE ;
WALSH, PJ .
ACTA OTO-LARYNGOLOGICA, 1978, 86 (1-2) :22-34
[5]   RESPONSE OF COCHLEAR POTENTIALS TO PRESUMED ALTERATIONS OF IONIC CONDUCTANCE - ENDOLYMPHATIC PERFUSION OF BARIUM, VALINOMYCIN AND NYSTATIN [J].
MARCUS, DC ;
ROKUGO, M ;
GE, XX ;
THALMANN, R .
HEARING RESEARCH, 1983, 12 (01) :17-30
[6]   CHARACTERIZATION OF POTASSIUM PERMEABILITY OF COCHLEAR DUCT BY PERILYMPHATIC PERFUSION OF BARIUM [J].
MARCUS, DC .
AMERICAN JOURNAL OF PHYSIOLOGY, 1984, 247 (03) :C240-C246
[7]   ELECTROPHYSIOLOGICAL MEASUREMENTS OF THE STRIA VASCULARIS POTENTIALS INVIVO [J].
MELICHAR, I ;
SYKA, J .
HEARING RESEARCH, 1987, 25 (01) :35-43
[8]   POSITIVE ENDOCOCHLEAR POTENTIAL - MECHANISM OF PRODUCTION BY MARGINAL CELLS OF STRIA VASCULARIS [J].
OFFNER, FF ;
DALLOS, P ;
CHEATHAM, MA .
HEARING RESEARCH, 1987, 29 (2-3) :117-124
[9]   CELLULAR-LOCALIZATION OF RAT ISK PROTEIN IN THE STRIA VASCULARIS BY IMMUNOHISTOCHEMICAL OBSERVATION [J].
SAKAGAMI, M ;
FUKAZAWA, K ;
MATSUNAGA, T ;
FUJITA, H ;
MORI, N ;
TAKUMI, T ;
OHKUBO, H ;
NAKANISHI, S .
HEARING RESEARCH, 1991, 56 (1-2) :168-172
[10]  
SALT AN, 1987, LARYNGOSCOPE, V97, P984
12