INTERLEUKIN-10 - A NOVEL STIMULATORY FACTOR FOR MAST-CELLS AND THEIR PROGENITORS

被引：506

作者：

THOMPSONSNIPES, LA

DHAR, V

BOND, MW

MOSMANN, TR

MOORE, KW

RENNICK, DM

机构：

[1] DNAX Research Institute, Palo Alto, CA 94304

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1991年 / 173卷 / 02期

关键词：

D O I：

10.1084/jem.173.2.507

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have characterized the mast cell stimulating activity of murine cytokine synthesis inhibitory factor, referred to as interleukin 10 (IL-10). It was found that IL-10 alone failed to support the growth of mast cell lines and mast cell progenitors. Nevertheless, it dramatically enhanced their growth when combined with IL-3 or IL-4. Moreover, IL-4 plus IL-10 supported the proliferation of mast cells as well as IL-3, suggesting that these two factors may provide a pathway for their development independent of IL-3. However, optimal mast cell growth was stimulated by the combination of IL-10, IL-4, and IL-3. This particular set of cytokines are coordinately produced by activated T cells and may constitute an effective network regulating early and late stages of mast cell development during certain immune responses.

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页码：507 / 510

页数：4

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