IMMUNOLOGICAL ADJUVANTS - A ROLE FOR LIPOSOMES

被引：394
作者：
GREGORIADIS, G
机构：
[1] The School of Pharmacy, University of London, London, WC1N 1AX
来源：
IMMUNOLOGY TODAY | 1990年 / 11卷 / 03期
关键词：
D O I：
10.1016/0167-5699(90)90034-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent technological advances have resulted in the production of safe subunit and synthetic small peptide vaccines. These vaccines are weakly or non-immunogenic and cannot, therefore, be used effectively in the absence of immunological adjuvants (agents that can induce strong immunity to antigens). Owing to the toxicity of adjuvants, only one (aluminium salts) has hitherto been licensed for use in humans, and it is far from ideal. In this article, Gregory Gregoriadis discusses the use of liposomes as an alternative safe, versatile, universal adjuvant that can induce humoral- and cell-mediated immunity to antigens when administered parenterally or enterally. © 1990.
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页码：89 / 97
页数：9
相关论文
共 79 条
[1]   LIPOSOMES AS IMMUNOLOGICAL ADJUVANTS [J].
ALLISON, AC ;
GREGORIADIS, G .
NATURE, 1974, 252 (5480) :252-252
[2]   AN ADJUVANT FORMULATION THAT SELECTIVELY ELICITS THE FORMATION OF ANTIBODIES OF PROTECTIVE ISOTYPES AND OF CELL-MEDIATED-IMMUNITY [J].
ALLISON, AC ;
BYARS, NE .
JOURNAL OF IMMUNOLOGICAL METHODS, 1986, 95 (02) :157-168
[3]   EFFECTIVENESS OF LIPOSOMES AS POTENTIAL CARRIERS OF VACCINES - APPLICATIONS TO CHOLERA-TOXIN AND HUMAN MALARIA SPOROZOITE ANTIGEN [J].
ALVING, CR ;
RICHARDS, RL ;
MOSS, J ;
ALVING, LI ;
CLEMENTS, JD ;
SHIBA, T ;
KOTANI, S ;
WIRTZ, RA ;
HOCKMEYER, WT .
VACCINE, 1986, 4 (03) :166-172
[4]  
[Anonymous], 1974, METHODS MEMBRANE BIO, DOI [DOI 10.1007/978-1-4615-7422-4_1, 10.1007/978-1-4615-7422-4_1]
[5]  
[Anonymous], 1988, LIPOSOMES DRUG CARRI
[6]   IMPAIRMENT OF IMMUNOGENICITY BY ANTIGEN PRESENTATION IN LIPOSOMES MADE FROM DIMYRISTOYLPHOSPHATIDYL-ETHANOLAMINE LINKED TO THE SECRETION OF PROSTAGLANDINS BY MACROPHAGES [J].
BAKOUCHE, Q ;
DAVID, F ;
GERLIER, D .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1987, 17 (12) :1839-1842
[7]  
BEATTY JD, 1984, SURGERY, V96, P345
[8]  
BOMFORD R, 1985, ANIMAL CELL BIOTECHN, V2, P235
[9]  
DAILEY MO, 1977, J IMMUNOL, V118, P957
[10]   LIPOSOMES AS ADJUVANTS WITH IMMUNOPURIFIED TETANUS TOXOID - THE IMMUNE-RESPONSE [J].
DAVIS, D ;
DAVIES, A ;
GREGORIADIS, G .
IMMUNOLOGY LETTERS, 1987, 14 (04) :341-348
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