CAN LINOLEIC-ACID AND GAMMA-LINOLENIC ACID BE IMPORTANT IN CANCER-TREATMENT

被引：10

作者：

VANASWEGEN, CH

DUPLESSIS, DJ

机构：

[1] Department of Urology, HF Verwoerd Hospital, Private bag X169, University of Pretoria, Pretoria

来源：

MEDICAL HYPOTHESES | 1994年 / 43卷 / 06期

关键词：

D O I：

10.1016/0306-9877(94)90018-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This hypothesis proposes that the essential fatty acids (EFAs), linoleic acid (LA) and gamma-linolenic acid (GLA), play important roles in cancer treatment. Oxidation of LA by lipoxidase especially increases tumour cell death, whilst GLA inhibits urokinase-type plasminogen activator (uPA) activity. Increased uPA activity is: firstly, responsible for cancer invasion and metastasis and secondly, responsible for proteolysis of lipoxidase which favours a decrease in cancer cell death. Addition of LA and GLA to available therapeutic regimens may be worth considering in cancer treatment.

引用

页码：415 / 417

页数：3

共 22 条

[1]

AZNAVOORIAN S, 1993, CANCER-AM CANCER SOC, V71, P1368, DOI 10.1002/1097-0142(19930215)71:4<1368::AID-CNCR2820710432>3.0.CO

[2]

2-L

[3] GROWTH-RELATED LIPID PEROXIDATION IN TUMOR MICROSOMAL-MEMBRANES AND MITOCHONDRIA [J].