AN EXPERIMENTAL-DESIGN APPLIED TO THE STATISTICAL-ANALYSIS OF INERT MATRICES DISSOLUTION DATA

被引：0

作者：

FRUTOS, G

PABON, CV

FRUTOS, P

LASTRES, JL

机构：

[1] UNIV COMPLUTENSE MADRID,FAC FARM,DPTO FARM & TECNOL FARMACEUT,E-28040 MADRID,SPAIN

[2] UNIV COMPLUTENSE MADRID,FAC FARM,DPTO MATEMAT & INVEST OPERAT,E-28040 MADRID,SPAIN

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1995年 / 21卷 / 20期

关键词：

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This study deals with oral controlled release matrix tablets which associate two kinds of polymeric excipients one hydrophobic (polyamide 12) and the other hydrophyllic (hydroxypropylmethil cellulose), The active principle is metoclopramide dyhydrochloride which is particularly appro-priate for its administration as controlled release dosage forms, due to its physicochemical properties and its therapeutic interest (1), The influence of experimental runs, dissolution vessels and polymer percentage has been evaluated in a complex form by means of a latin square experimental design. Model independent parameters and other parameters derived from Gompertz fitting function, are subjected to corresponding analysis of variance (ANOVA) to determine significant effects of the factors.

引用

页码：2287 / 2306

页数：20

共 6 条

[1] Banakar UV, 1992, PHARM DISSOLUTION TE
[2] DIXON WJ, 1981, BMDP BIOMEDICAL COMP
[3] EXPERIMENTAL-DESIGN IN DISSOLUTION TESTING
LEWIS, GA
STEVENS, HNE
[J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1987, 13 (9-11) : 1807 - 1816
[4] INVITRO STUDY OF MIXED CONTROLLED RELEASE MATRIX TABLETS CONTAINING HMPC AND POLYAMIDE-12
PABON, CV
FRUTOS, P
LASTRES, JL
FRUTOS, G
[J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1992, 18 (20) : 2163 - 2171
[5] PRITE D, 1987, ANAL PROFILES DRUG S, V16
[6] LOGISTIC FUNCTION-ANALYSIS OF GERMINATION BEHAVIOR OF AGED FENNEL SEEDS
TORRES, M
FRUTOS, G
[J]. ENVIRONMENTAL AND EXPERIMENTAL BOTANY, 1990, 30 (03) : 383 - 390

← 1 →