STRUCTURAL INVESTIGATION OF MODEL DEADENYLATED OLIGONUCLEOTIDE PHOSPHOROTHIOATE ANALOG OF ISIS-2105

被引：0
作者：
RAVIKUMAR, VT
WYRZYKIEWICZ, TK
MOHAN, V
COLE, DL
机构：
[1] Isis Pharmaceuticals, Carlsbad, CA 92008
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1994年 / 13卷 / 10期
关键词：
D O I：
10.1080/15257779408013217
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Structural characteristics of deadenylated oligonucleotide of ISIS 2105 is provided by the chemical synthesis of a model deadenylated analog. The results of molecular mechanics calculations incorporating the abasic site in the duplex are presented.
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页码：2195 / 2207
页数：13
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