SPARING OF NADPH-DIAPHORASE STRIATAL NEURONS IN PARKINSONS AND ALZHEIMERS DISEASES

被引：69
作者：
MUFSON, EJ
BRANDABUR, MM
机构：
[1] RUSH PRESBYTERIAN ST LUKES MED CTR,RUSH ALZHEIMERS DIS CTR,CHICAGO,IL 60612
[2] RUSH PRESBYTERIAN ST LUKES MED CTR,MOVEMENT DISORDERS SECT,CHICAGO,IL 60612
来源：
NEUROREPORT | 1994年 / 5卷 / 06期
关键词：
PARKINSONS DISEASE; ALZHEIMERS DISEASE; STRIATUM; NADPH-DIAPHORASE;
D O I：
10.1097/00001756-199402000-00011
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
THE free radical neuromodulator, nitric oxide (NO) has been implicated as a neurotoxin. Neurons containing NO synthase (NOS) also contain NADPH-diaphorase (NADPH-d) and are resistant to NO toxicity. We report that NADPH-d-containing neurons within the striatum are spared in patients with Parkinson's (PD) and Alzheimer's disease (AD). However, a number of these neurons in both diseases appeared shrunken or bulbous with foreshortened dendritic processes. Quantitative analysis of cell areas revealed a significant difference only in the size of putamenal AD neurons which were decreased compared to normal controls. The possible involvement of NO in the neuropathogenesis of striatal derangement is discussed.
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页码：705 / 708
页数：4
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