HEPATITIS-B AND HEPATITIS-C VIRUSES AND THEIR INTERACTION IN THE ORIGIN OF HEPATOCELLULAR-CARCINOMA

被引:198
作者
KAKLAMANI, E
TRICHOPOULOS, D
TZONOU, A
ZAVITSANOS, X
KOUMANTAKI, Y
HATZAKIS, A
HSIEH, CC
HATZIYANNIS, S
机构
[1] HARVARD UNIV,SCH PUBL HLTH,DEPT EPIDEMIOL,677 HUNTINGTON AVE,BOSTON,MA 02115
[2] UNIV ATHENS,SCH MED,DEPT HYG & EPIDEMIOL,ATHENS,GREECE
[3] IPPOKRATEION HOSP,ACAD DEPT MED,ATHENS,GREECE
来源
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 1991年 / 265卷 / 15期
关键词
D O I
10.1001/jama.265.15.1974
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Serum taken from patients in a case-control study in Athens, Greece, was used to examine the interactive roles of hepatitis B virus (HBV) and hepatitis C virus (HCV) in the origin of hepatocellular carcinoma (HCC). An enzyme immunoassay for anti-HCV was used to test serum taken from 185 cases with HCC, 35 cases with metastatic liver cancer (MLC), and 432 hospital controls. Weakly positive anti-HCV results were more strongly related to MLC than to HCC, implying that these anti-HCV results are false positive. By contrast, strongly positive anti-HCV results were significantly related to HCC (relative risk [RR], 6.3), whereas no significant association was evident for MLC (RR, 0.6). The association of anti-HCV with HCC was substantially higher among subjects whose radioimmunoassay was positive for hepatitis B surface antigen (RR, 20.0) than among those whose radioimmunoassay was negative for this marker (RR, 4.8). These findings indicate that HCV infection has an interactive role in the origin of HCC.
引用
收藏
页码:1974 / 1976
页数:3
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