AROYLALKYLPYRRODLDINES . CENTRAL NERVOUS SYSTEM DEPRESSANTS

被引：15

作者：

WELSTEAD, WJ

HELSLEY, GC

DUNCAN, RL

CALE, AD

TAYLOR, CR

DAVANZO, JP

FRANKO, BV

LUNSFORD, CD

机构：

[1] Research Laboratories, A. H. Robins Company, Inc., Richmond, Virginia

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 03期

关键词：

D O I：

10.1021/jm00303a023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The title compounds were prepared by alkylating 3-substituted pyrrolidines with the ketal of γ-chlorobutyrophenones. Several compounds show CNB depressant activity comparable to chlorpromazine. Hypotensive effects were also observed in many of the compounds. © 1969, American Chemical Society. All rights reserved.

引用

收藏

页码：435 / &

相关论文

共 13 条

[1] NUCLEOPHILIC DISPLACEMENTS OF ACTIVATED FLUORINE IN AROMATIC COMPOUNDS [J].

BADER, H ;

HANSEN, AR ;

MCCARTY, FJ .

JOURNAL OF ORGANIC CHEMISTRY, 1966, 31 (07) :2319-&

[2] CHEMISTRY AND PHARMACOLOGY OF 4-ALKOXYPIPERIDINES RELATED TO REVERSED ESTERS OF PETHIDINE [J].

CASY, AF ;

VALLANCE, DK ;

HALL, GH ;

BECKETT, AH .

JOURNAL OF MEDICINAL & PHARMACEUTICAL CHEMISTRY, 1961, 4 (03) :535-&

[3] AN IMPROVED SYNTHESIS OF CYCLOPROPYL PHENYL KETONE AND RELATED SUBSTANCES [J].

CLOSE, WJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1957, 79 (06) :1455-1458

[4] PHARMACOLOGICAL AND BIOCHEMICAL STUDIES IN ISOLATION-INDUCED FIGHTING MICE [J].

DAVANZO, JP ;

DAUGHERTY, M ;

RUCKART, R ;

KANG, L .

PSYCHOPHARMACOLOGIA, 1966, 9 (03) :210-210

[5] SYNTHESIS AND BIOLOGICAL PROPERTIES OF SOME 1-SUBSTITUTED 3-(O-METHOXYPHENOXY)PYRROLIDINES [J].

DUNCAN, RL ;

HELSLEY, GC ;

WELSTEAD, WJ ;

FRANKO, BV .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (03) :442-&

[6]

Goldblatt H, 1934, J EXP MED, V59, P347, DOI 10.1084/jem.59.3.347

[7]

GORDON M, 1967, MEDICINAL CHEMIST ED, P199

[8] ANALGETICS . ESTERS OF 3-PYRROLIDINEMETHANOLS [J].

HELSLEY, GC ;

RICHMAN, JA ;

LUNSFORD, CD ;

JENKINS, H ;

MAYS, RP ;

FUNDERBURK, WH ;

JOHNSON, DN .

JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (03) :472-+

[9] GRIGNARD REAGENT DERIVED FROM THE ETHYLENE KETAL OF OMEGA-BROMOBUTYROPHENONE [J].

HOUSE, HO ;

BLAKER, JW .

JOURNAL OF ORGANIC CHEMISTRY, 1958, 23 (03) :334-335

[10] CHEMISTRY AND PHARMACOLOGY OF CNS DEPRESSANTS RELATED TO 4-(4-HYDROXY-4-PHENYLPIPERIDINO)BUTYROPHENONE .1. SYNTHESIS AND SCREENING DATA IN MICE [J].

JANSSEN, PAJ ;

VANDEWESTERINGH, C ;

JAGENEAU, AHM ;

DEMOEN, PJA ;

HERMANS, BKF ;

VANDAELE, GHP ;

SCHELLEKENS, KHL ;

VANDEREYCKEN, CAM ;

NIEMEGEERS, CJE .

JOURNAL OF MEDICINAL & PHARMACEUTICAL CHEMISTRY, 1959, 1 (03) :281-297