THE SYNTHESIS OF A KEY INTERMEDIATE OF TRICYCLIC BETA-LACTAM ANTIBIOTICS

被引：35

作者：

BISMARA, C ^{[1
]}

DIFABIO, R ^{[1
]}

DONATI, D ^{[1
]}

ROSSI, T ^{[1
]}

THOMAS, RJ ^{[1
]}

机构：

[1] GLAXO SPA,GLAXO RES LABS,I-37135 VERONA,ITALY

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 24期

关键词：

D O I：

10.1016/0040-4039(95)00740-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

By employing an intramolecular Sakurai-type olefination it was possible to obtain the olefin 5, a key intermediate in the synthesis of the broad spectrum tricyclic beta-lactam antibiotic GG-326 1.

引用

页码：4283 / 4286

页数：4

共 8 条

[1] IN-VITRO ACTIVITY OF THE TRIBACTAM GV104326 AGAINST GRAM-POSITIVE, GRAM-NEGATIVE, AND ANAEROBIC-BACTERIA [J].

DIMODUGNO, E ;

ERBETTI, I ;

FERRARI, L ;

GALASSI, G ;

HAMMOND, SM ;

XERRI, L .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (10) :2362-2368

[2]

IMUTA M, 1993, MED BIO MED CHEM LET, V3, P2199

[3] CARBON-CARBON BOND FORMATION AT THE C-4 POSITION OF AN AZETIDIN-2-ONE RING BY INTERMOLECULAR RADICAL COUPLING REACTIONS - A ROUTE TO TRIBACTAMS [J].

PADOVA, A ;

ROBERTS, SM ;

DONATI, D ;

PERBONI, A ;

ROSSI, T .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1994, (04) :441-442

[4]

Patai S., 1989, CHEM ORGANIC SILICON, V2, P1479

[5]

Perboni A., 1992, RECENT ADV CHEM ANTI, P21

[6] A SIMPLE AND STEREOCONTROLLED SYNTHESIS OF A 1-BETA-METHYLCARBAPENEM KEY INTERMEDIATE BY MEANS OF ORGANOSILICON CHEMISTRY [J].

UYEO, S ;

ITANI, H .

TETRAHEDRON LETTERS, 1991, 32 (19) :2143-2144

[7]

UYEO S, 1990, Patent No. 4960880

[8] SELECTIVE REACTIONS USING ALLYLIC METALS [J].

YAMAMOTO, Y ;

ASAO, N .

CHEMICAL REVIEWS, 1993, 93 (06) :2207-2293

← 1 →