PROPAGATION OF ACTIVATION IN CARDIAC-MUSCLE

The hypothesis of local circuit current flow underlying propagation of activation in cardiac muscle has been extensively documented by one-dimensional and two-dimensional simulation studies. The assumptions of spatially uniform membrane capacitance and membrane ionic properties yield simulation results that are in good agreement with experimental observations in healthy cardiac muscle, thereby indicating that differences in propagation velocity and action potential upstroke between longitudinal and transverse directions can be explained solely on the basis of anisotropic intercellular coupling. Two-dimensional model studies of anisotropic propagation have also stressed the more efficient charging of the membrane capacitance and higher safety factor of propagation in the transverse direction. These conditions favor the occurrence of longitudinal unidirectional block and the initiation of reentry via transverse propagation. The authors simulated rotating waves initiated by properly phased transverse and longitudinal plane waves in a two-dimensional sheet model. Sustained propagation requires a minimum anisotropy ratio, corresponding to a velocity ratio of about 4:1. It was found, for uniform anisotropy, that the central focus wandered slightly. A higher anisotropy ratio favors a more stable rotating pattern and a more restricted movement of the central focus.