Proapoptotic role of nuclear clusterin in brain

被引：23
作者：
Kim, Nayoung [1 ]
Choi, Wan Sung [1 ]
机构：
[1] Gyeongsang Natl Univ, Sch Med, Inst Hlth Sci, Dept Anat & Neurobiol,Med Res Ctr Neural Dysfunct, 92 Chiram Dong, Jinju 660751, South Korea
来源：
ANATOMY & CELL BIOLOGY | 2011年 / 44卷 / 03期
基金：
新加坡国家研究基金会;
关键词：
Clusterin; Apoptosis; Brain;
D O I：
10.5115/acb.2011.44.3.169
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Clusterin (CLU) is a multifunctional glycoprotein that has secretory and nuclear isoforms. The two isoforms are known to play opposite roles in cell survival/death. In this review, we summarize recent progress on the pro-apoptotic function of nuclear CLU in vitro and in vivo and discuss previous reports on the role of CLU in brain damage and neurodegeneration.
引用
收藏
页码：169 / 175
页数：7
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