SPECTROPHOTOMETRIC DETERMINATION OF NICOUMALONE, ACEBUTOLOL HYDROCHLORIDE AND PROCAINAMIDE HYDROCHLORIDE

被引：16
|
作者：
SASTRY, CSP
RAO, TT
SAILAJA, A
机构：
[1] Foods and Drugs Laboratories, School of Chemistry, Andhra University, Visakhapatnam
来源：
TALANTA | 1991年 / 38卷 / 09期
关键词：
D O I：
10.1016/0039-9140(91)80325-T
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A sensitive spectrophotometric method is described for the determination of nicoumalone (NIC), acebutolol hydrochloride (ACBH) or procainamide hydrochloride (PAH) either in pure form or in pharmaceutical formulations. The method is based on the oxidative coupling reaction through the involvement of an aromatic primary amino group (released through reduction in NIC or hydrolysis in ACBH or existing free in PAH) in the drug with 3-methyl-2-benzothiazolinone hydrozone hydrochloride (MBTH) in the presence of ferric chloride [Fe(III)]. The resulting chromophores are measured at 620 nm for NIC and ACBH and 580 nm for PAH. The concentration measurements are reproducible within a relative standard deviation of 1%.
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页码：1057 / 1060
页数：4
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