SEQUENCE OF THE GOAT ALPHA-LACTALBUMIN-ENCODING GENE - COMPARISON WITH THE BOVINE GENE AND EVIDENCE OF RELATED SEQUENCES IN THE GOAT GENOME

被引：39
作者：
VILOTTE, JL
SOULIER, S
PRINTZ, C
MERCIER, JC
机构：
来源：
GENE | 1991年 / 98卷 / 02期
关键词：
MILK PROTEINS; MILK-BOX; EXON; INTRON; DUPLICATION; RECOMBINANT DNA; PSEUDOGENE;
D O I：
10.1016/0378-1119(91)90185-E
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The isolation and characterization of a genomic clone encoding goat alpha-lactalbumin (alpha-LA) are described, and its sequence was aligned with that of its bovine counterpart. The 5' -flanking regions are highly homologous, but two small insertions were found in the goat sequence. One of these insertions fills the gap found in the so-called 'milk-box' consensus sequence of the bovine gene. Southern analysis indicates the presence of several alpha-LA-related sequences in the goat genome, as previously observed in cow and sheep, which suggests that the relevant duplication event(s) occurred before divergence of these ruminant species.
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收藏
页码：271 / 276
页数：6
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