ARTIFACTS PRODUCED BY USING DICHLOROMETHANE IN THE EXTRACTION AND STORAGE OF SOME ANTIHISTAMINIC DRUGS

被引：20

作者：

BECKETT, AH ^{[1
]}

ALI, HM ^{[1
]}

机构：

[1] UNIV LONDON CHELSEA COLL SCI & TECHNOL, DEPT PHARM, LONDON SW3 6LX, ENGLAND

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 177卷 / 02期

关键词：

D O I：

10.1016/S0021-9673(01)96321-6

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The use of dichloromethane for the extraction of amines may lead to the formation of artifacts. Dichloromethane reacts rapidly (37.5.degree. C) with brompheniramine, diphenylpyraline, cyclizine, cyproheptadine but not with antazoline and lignocaine. This difference in reactivity and the TLC, GLC, NMR and mass spectrometric characteristics of cyclizine and diphenylpyraline chloromethochlorides are studied.

引用

页码：255 / 262

页数：8

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