TREATMENT OF INVASIVE ASPERGILLOSIS WITH ITRACONAZOLE IN A PATIENT WITH CHRONIC GRANULOMATOUS-DISEASE

被引：34

作者：

VANTWOUT, JW ^{[1
]}

RAVEN, EJM ^{[1
]}

VANDERMEER, JWM ^{[1
]}

机构：

[1] HOSP GODDELIJKE VOORZIENIGHEID,DEPT PAEDIAT,SITTARD,NETHERLANDS

来源：

JOURNAL OF INFECTION | 1990年 / 20卷 / 02期

关键词：

D O I：

10.1016/0163-4453(90)93418-R

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

An 18-year-old boy with X-linked chronic granulomatous disease (CGD) developed Aspergillus fumigatus pneumonia and multifocal osteomyelitis. Treatment with amphotericin B resulted in only moderate improvement of the lesions and was accompanied by considerable toxicity. In contrast, administration of the new triazole drug itraconazole led to complete disappearance of all signs of infection. We conclude that itraconazole may be a valuable new drug for treating invasive aspergillosis in patients with CGD, although the duration of treatment remains to be established. © 1990 The British Society for the Study of Infection.

引用

页码：147 / &

共 11 条

[1] FUNGAL INFECTION IN CHRONIC GRANULOMATOUS-DISEASE - THE IMPORTANCE OF THE PHAGOCYTE IN DEFENSE AGAINST FUNGI [J].

COHEN, MS ;

ISTURIZ, RE ;

MALECH, HL ;

ROOT, RK ;

WILFERT, CM ;

GUTMAN, L ;

BUCKLEY, RH .

AMERICAN JOURNAL OF MEDICINE, 1981, 71 (01) :59-66

[2]

DEBEULE K, 1988, MYCOSES, V31, P476, DOI 10.1111/j.1439-0507.1988.tb03653.x

[3] AZOLE ANTIFUNGAL DRUGS - OLD AND NEW [J].

DISMUKES, WE .

ANNALS OF INTERNAL MEDICINE, 1988, 109 (03) :177-179

[4] PHARMACOKINETICS OF ITRACONAZOLE FOLLOWING ORAL-ADMINISTRATION TO NORMAL VOLUNTEERS [J].

HARDIN, TC ;

GRAYBILL, JR ;

FETCHICK, R ;

WOESTENBORGHS, R ;

RINALDI, MG ;

KUHN, JG .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (09) :1310-1313

[5] HAIR LOSS DURING ITRACONAZOLE TREATMENT [J].

HEILESEN, AM .

BRITISH MEDICAL JOURNAL, 1986, 293 (6550) :823-823

[6]

SPELLER DCE, 1986, J ANTIMICROB CHEMOTH, V17, P514

[7] CHRONIC GRANULOMATOUS-DISEASE - A SYNDROME OF PHAGOCYTE OXIDASE DEFICIENCIES [J].

TAUBER, AI ;

BORREGAARD, N ;

SIMONS, E ;

WRIGHT, J .

MEDICINE, 1983, 62 (05) :286-309

[8]

VANDENBOSSCHE H, 1987, RECENT TRENDS DISCOV, P207

[9] COMPARISON OF THE EFFICACIES OF AMPHOTERICIN-B, FLUCONAZOLE, AND ITRACONAZOLE AGAINST A SYSTEMIC CANDIDA-ALBICANS INFECTION IN NORMAL AND NEUTROPENIC MICE [J].

VANTWOUT, JW ;

MATTIE, H ;

VANFURTH, R .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (02) :147-151

[10] EXPERIENCE WITH ITRACONAZOLE IN CRYPTOCOCCOSIS AND ASPERGILLOSIS [J].

VIVIANI, MA ;

TORTORANO, AM ;

LANGER, M ;

ALMAVIVA, M ;

NEGRI, C ;

CRISTINA, S ;

SCOCCIA, S ;

DEMARIA, R ;

FIOCCHI, R ;

FERRAZZI, P ;

GOGLIO, A ;

GAVAZZENI, G ;

FAGGIAN, G ;

RINALDI, R ;

CADROBBI, P .

JOURNAL OF INFECTION, 1989, 18 (02) :151-&

← 1 2 →