2,3 DIMERCAPTO-1-PROPANOL INHIBITS HIV-1 TAT ACTIVITY, VIRAL PRODUCTION, AND INFECTIVITY INVITRO

被引：23

作者：

KUBOTA, S

ELFARRASH, MA

MAKI, M

HARADA, S

HATANAKA, M

机构：

[1] KYOTO UNIV,INST VIRUS RES,SHOGOIN,SAKYO KU,KYOTO 606,JAPAN

[2] KUMAMOTO UNIV,SCH MED,DEPT MED VIROL,KUMAMOTO 860,JAPAN

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1990年 / 6卷 / 07期

关键词：

D O I：

10.1089/aid.1990.6.919

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have examined the effect of 2,3 dimercapto-1-propanol (DMP), which is known as an anti-heavy metal-poisoning drug, against human immunodeficiency virus type 1 (HIV-1). We demonstrate that DMP inhibited transactivation directed by tat protein, which is a metal containing transcriptional transactivating factor and also interfered with viral production. Furthermore, treatment and pretreatment of cells with DMP strongly reduced their sensitivity for HIV-1 infection through unknown mechanisms. These results indicate that DMP reveals pleuripotent effects on HIV-1 infection and production in vitro and thus may provide an exploitable hypothesis for designing new drugs against AIDS. © 1990, Mary Ann Liebert, Inc. All rights reserved.

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页码：919 / 927

页数：9

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