NUCLEAR-CHANGES IN APOPTOSIS

被引：490
作者：
EARNSHAW, WC
机构：
[1] WC Earnshaw, Department of Cell Biology and Anatomy, Johns Hopkins University School of Medicine, Baltimore, MD 21205
来源：
CURRENT OPINION IN CELL BIOLOGY | 1995年 / 7卷 / 03期
关键词：
D O I：
10.1016/0955-0674(95)80088-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Specific proteinases of the Ced-3/interleukin-1 beta converting enzyme family trigger a multi-enzyme cascade that drives apoptotic events. Studies with newly developed cell-free systems have begun to identify the substrates of these and other proteinases in apoptosis. Studies with intact cells have revealed that cleavage of the genome into domain-sized fragments precedes the activation of a second nuclease that fragments the DNA into nucleosome-sized pieces.
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页码：337 / 343
页数：7
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