TAXOL ENCAPSULATION IN POLY(EPSILON-CAPROLACTONE) MICROSPHERES

被引:76
作者
DORDUNOO, SK
JACKSON, JK
ARSENAULT, LA
OKTABA, AMC
HUNTER, WL
BURT, HM
机构
[1] UNIV BRITISH COLUMBIA,FAC PHARMACEUT SCI,VANCOUVER,BC V6T 1Z3,CANADA
[2] MCMASTER UNIV,DEPT PATHOL,HAMILTON,ON,CANADA
[3] ANGIOGENESIS TECHNOL INC,VANCOUVER,BC,CANADA
关键词
TAXOL; MICROSPHERES; ANTIANGIOGENESIS;
D O I
10.1007/s002800050323
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Poly(epsilon-caprolactone) (PCL) microspheres containing taxol were prepared by the solvent evaporation method and tested for angiogenesis inhibition using the chick chorioallantoic membrane (CAM) model. Very high encapsulation efficiencies (95%) for taxol in PCL microspheres were obtained. In vitro release studies showed about 25% of the loaded drug was released in 6 weeks from microspheres containing 5% taxol. Studies with the CAM showed that taxol released from the microspheres induced vascular regression and inhibited angiogenesis.
引用
收藏
页码:279 / 282
页数:4
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