INTERACTION BETWEEN GRANULOCYTES AND ANTIBODIES IN THE ENHANCEMENT OF LUNG DEFENSES AGAINST STAPHYLOCOCCUS-AUREUS AFTER INTRANASAL IMMUNIZATION OF MICE WITH LIVE-ATTENUATED BACTERIA

被引：4

作者：

GARCIA, VE ^{[1
]}

IGLESIAS, MF ^{[1
]}

CERQUETTI, MC ^{[1
]}

GOMEZ, MI ^{[1
]}

SORDELLI, DO ^{[1
]}

机构：

[1] CONSEJO NACL INVEST CIENT & TECN,CTR ESTUDIOS FARMACOL & BOT,BUENOS AIRES,ARGENTINA

来源：

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 1994年 / 9卷 / 01期

关键词：

STAPHYLOCOCCUS AUREUS; PSEUDOMONAS AERUGINOSA; ANTIBODY; MUCOSAL IMMUNITY; GRANULOCYTE;

D O I：

10.1016/0928-8244(94)90081-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunization with live-attenuated Staphylococcus aureus induced measurable levels of specific IgG and IgA in the lungs, but the pulmonary clearance of S. aureus in immunized mice did not differ from that of control mice. Aerosol exposure of mice to Pseudomonas aeruginosa induced a significant recruitment of polymorphonuclear leukocytes (PMNL) to the lungs in both immunized and control mice, whereas S. aureus challenge did not. However, challenge with a mixture of P. aeruginosa-S. aureus or exposure to an aerosol of Escherichia coli lipopolysaccharide (LPS) before S. aureus challenge induced PMNL migration and a significant enhancement of pulmonary clearance of S. aureus in immunized mice. The presence of both antibodies and PMNL was required for enhancement of S. aureus pulmonary clearance.

引用

页码：55 / 63

页数：9

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