SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF UNSATURATED KETOHEXOPYRANOSYL NUCLEOSIDES OF PYRIMIDINES

被引:8
作者
SHARMA, AP [1 ]
OLLAPALLY, AP [1 ]
JONES, W [1 ]
LEMON, T [1 ]
机构
[1] FLORIDA A&M UNIV,DEPT CHEM,TALLAHASSEE,FL 32307
来源
NUCLEOSIDES & NUCLEOTIDES | 1992年 / 11卷 / 05期
关键词
D O I
10.1080/07328319208021165
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Synthesis of unsaturated ketohexopyranosyl nucleosides of a few pyrimidines is described. The results of their bioevaluation for anticancer and antiviral activity are also discussed.
引用
收藏
页码:1009 / 1038
页数:30
相关论文
共 14 条
[1]   ABSENCE OF GENOTOXIC EFFECTS IN CELLS EXPOSED TO 4 KETONUCLEOSIDE DERIVATIVES [J].
ALAOUIJAMALI, MA ;
LASNE, C ;
ANTONAKIS, K ;
CHOUROULINKOV, I .
MUTAGENESIS, 1986, 1 (06) :411-417
[2]   STUDIES ON INHIBITION OF GROWTH OF KB CELLS BY 9-(KETO-NUCLEOSIDES) AND 7-(KETO-NUCLEOSIDES) [J].
ANTONAKIS, K ;
CHOUROULINKOV, I .
BIOCHEMICAL PHARMACOLOGY, 1974, 23 (15) :2095-2100
[3]  
ANTONAKIS K, 1980, EUR J MED CHEM, V15, P237
[4]   SYNTHESIS OF UNSATURATED 4'-AZIDO PYRANOSYL THYMINES AS POTENTIAL ANTIVIRAL AND ANTI-HIV AGENTS [J].
BESSODES, M ;
EGRON, MJ ;
FILIPPI, J ;
ANTONAKIS, K .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1990, (11) :3035-3039
[5]   UNSATURATED KETONUCLEOSIDES OF ADENINE AND HYPOXANTHINE [J].
BESSODES, M ;
LAKAF, R ;
ANTONAKIS, K .
CARBOHYDRATE RESEARCH, 1986, 148 (01) :148-152
[6]  
CHOUROULINKOV I, 1977, CR ACAD SCI D NAT, V285, P1021
[7]  
DELATRE S, 1991, NUCLEOS NUCLEOT, V10, P431
[8]   INTERACTIONS OF CYTOSTATIC UNSATURATED KETONUCLEOSIDES WITH SULFHYDRYL CONTAINING CELL CONSTITUENTS [J].
HALMOS, T ;
CARDON, A ;
ANTONAKIS, K .
CHEMICO-BIOLOGICAL INTERACTIONS, 1983, 46 (01) :11-29
[9]   AN IMPROVED METHOD FOR THE PREPARATION OF 2',3'-UNSATURATED NUCLEOSIDES - SYNTHESIS OF STEREOSPECIFICALLY LABELED KETONUCLEOSIDES [J].
HERSCOVICI, J ;
MONTSERRET, R ;
ANTONAKIS, K .
CARBOHYDRATE RESEARCH, 1988, 176 (02) :219-229
[10]   MOLECULAR SIEVE-ASSISTED OXIDATIONS - NEW METHODS FOR CARBOHYDRATE DERIVATIVE OXIDATIONS [J].
HERSCOVICI, J ;
ANTONAKIS, K .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1980, (12) :561-562